• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Promotion of lung tumor growth by interleukin-17
Recent findings demonstrate that inhaled cigarette smoke, the predominant lung carcinogen, elicits a T helper 17 (Th17) inflammatory phenotype. Interleukin-17A (IL-17), the hallmark cytokine of Th17 inflammation, displays pro- and antitumorigenic properties in a manner that varies according to tumor type and assay system. To investigate the role of IL-17 in lung tumor growth, we used an autochthonous tumor model (K-RasLA1 mice) with lung delivery of a recombinant adenovirus that expresses IL-17A. Virus-mediated expression of IL-17A in K-RasLA1 mice at 8–10 wk of age doubled lung tumor growth in 3 wk relative to litte...
Source: AJP: Lung Cellular and Molecular Physiology - September 15, 2014 Category: Respiratory Medicine Authors: Xu, B., Guenther, J. F., Pociask, D. A., Wang, Y., Kolls, J. K., You, Z., Chandrasekar, B., Shan, B., Sullivan, D. E., Morris, G. F. Tags: ARTICLES Source Type: research

LPS induces pp60c-src-mediated tyrosine phosphorylation of Hsp90 in lung vascular endothelial cells and mouse lung
Heat shock protein 90 (Hsp90) inhibitors were initially developed as anticancer agents; however, it is becoming increasing clear that they also possess potent anti-inflammatory properties. Posttranslational modifications of Hsp90 have been reported in tumors and have been hypothesized to affect client protein- and inhibitor-binding activities. In the present study we investigated the posttranslational modification of Hsp90 in inflammation. LPS, a prototypical inflammatory agent, induced concentration- and time-dependent tyrosine (Y) phosphorylation of Hsp90α and Hsp90β in bovine pulmonary arterial and human lung...
Source: AJP: Lung Cellular and Molecular Physiology - June 15, 2013 Category: Respiratory Medicine Authors: Barabutis, N., Handa, V., Dimitropoulou, C., Rafikov, R., Snead, C., Kumar, S., Joshi, A., Thangjam, G., Fulton, D., Black, S. M., Patel, V., Catravas, J. D. Tags: ARTICLES Source Type: research