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Abstract 3164: Inflammasomes: fanning the flames of malignant mesothelioma initiation
Malignant mesothelioma (MM) is an aggressive and devastating cancer of the pleural/peritoneal mesothelium related to asbestos exposure. MM has a low survival rate (average: less than 12 months). Despite the causal relationship between asbestos and MM development, the exact mechanism by which asbestos causes MM is still poorly understood. There is an urgent need for the identification of mechanism(s) that may help in early detection and finding new treatment targets for prevention and treatment of MM.We have recently shown that asbestos exposure of human mesothelial cells (HMCs) leads to the activation of the NLRP3 inflamma...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Thompson, J. K., MacPherson, M. B., Beuschel, S. L., Shukla, A. Tags: Immunology Source Type: research

Abstract B56: Transfer of senescent signals in a hypoxic tumor microenvironment: A mechanism of tumor cell survival mediated by exosomes
The objective of this study was to establish if exosomes released from the TNBC cell line MDA-MB-231 (MSL) grown in a hypoxic environment, can mediate the transfer of viable cellular fate signatures (senescent and autophagic) to non-hypoxic cells rendering them non-apoptotic and chemoresistant. Experimentally, MDA-MB-231 (MSL) TNBC cells were cultured in hypoxia (1%) for 0-96 hours. Senescent, autophagic and cell cycle markers (LC3, p21, HDAC6, TSG101 and MAD2) were analysed by Western Blot. Nanoparticle Tracking Analysis (NTA), performed on the Nanosight LM10 microscope, allowed the enumeration and characterisation of har...
Source: Cancer Research - January 12, 2015 Category: Cancer & Oncology Authors: Gubbins, L., Weiner-Gorzel, K., Sharma, S., Cooke, L., Salvati, A., Simpson, J., Dawson, K., Kell, M., McCann, A. Tags: Cell Interactions in the Tumor Microenvironment Source Type: research

Abstract 2392: The role of ATM in lytic infection of EBV in nasopharyngeal epithelial cells
In this study, the essential role of ATM for viral DNA replication was examined in EBV-infected nasopharyngeal epithelial cells. Induction of lytic EBV infection triggers ATM activation and localization of DDR proteins at the viral replication compartments. Suppression of ATM activity using siRNA approach or specific chemical inhibitor diminished EBV DNA replication and production of infectious virion in EBV-infected cells induced to undergo lytic infection. Phosphorylation of Sp1 is a downstream event of ATM activation. The phosphorylation of Sp1 at serine 101 residue is crucial in promoting the accretion of EBV replicati...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Tsao, G. S.-W., Hau, P. M. Tags: Molecular and Cellular Biology Source Type: research

Abstract 2953: Rev-erb{alpha} modulates Myc-driven cancer cell growth and altered metabolism
Circadian rhythms are regulated by feedback loops comprising a network of factors that regulate Clock-associated genes. Chronotherapy seeks to take advantage of altered circadian rhythms in some cancers to better time administration of treatments to increase efficacy and reduce toxicity. While many cancers have perturbed expression of core circadian rhythm genes, the molecular basis underlying these perturbations and their functional implications in oncogenesis are still poorly understood, and so it is impossible to predict which cancers have altered circadian rhythms and would best benefit from chronotherapy. We have obse...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Altman, B. J., Hsieh, A., Gouw, A. M., Stine, Z. E., Venkataraman, A., Bellovin, D. I., Diskin, S. J., Lu, W., Zhang, S., Felsher, D. W., Maris, J. M., Lazar, M. A., Rabinowitz, J. D., Hogenesch, J. B., Dang, C. V. Tags: Molecular and Cellular Biology Source Type: research