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Abstract 905: Influence of high fat diet and APC status on epigenetic regulation of FXR in colon cells
We examined the effects on CpG pmethylation of Fxr, and expression of FXR, peroxisome-proliferator activated receptor-gamma (PPARγ), and cyclooxygenase-2 (COX-2) mRNA. Also, we studied the influence of APC status on CpG methylation of the Fxr gene, and expression of FXR, ileal bile acid-binding protein (IBABP), small heterodimer partner (SHP), and COX-2 mRNA in normal colonic mucosa and colon tumors from APCMin/+ mice. Mice fed the HFD had reduced (60%) Fxr promoter methylation and increased (2∼3-fold) FXR, COX-2, and PPARγ mRNA levels. Conversely, APC-deficiency was associated with constitutive hypermethylation of the...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Selmin, O. I., Lyon, A. M., Fang, C., Doetschman, T. C., Thompson, P. A., Martinez, J. D., Smith, J., Lance, P. M., Romagnolo, D. F. Tags: Prevention Research Source Type: research

Abstract 694: Structure-function analysis of RPL18A, a putative binding target of rigosertib
Rigosertib (ON 01910.Na; RGS) is a clinical stage anticancer agent that causes spindle abnormalities and mitotic arrest in neoplastic cells. The drug inhibits PI3K and PLK1 signaling pathways, down regulates cyclin D1 expression and induces apoptosis. Previously, we reported identification of RPL18A (L18A), a protein from the large ribosomal subunit, as a putative binding target of RGS [Proc. AACR 2014, #4595]. Knock-down of L18A with siRNA caused apoptosis in cancer cell lines. Role of L18A in the function of the ribosome is not known. Goal of this study was to conduct structure-function analysis of L18A and create defici...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Oussenko, I. A., Gupta, Y. K., Vasquez-Del Carpio, R., Ramana-Reddy, M. V., Aggarwal, A. K., Reddy, E. P., Holland, J. F., Ohnuma, T. Tags: Experimental and Molecular Therapeutics Source Type: research