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Abstract 3669: Engineering the biointerface of synthetic high density lipoprotein nanoparticles enables efficient nucleic acid loading, delivery, and target gene regulation in cancer cells
Local treatment of cancer confined to the primary organ can be curative. However, other than a few success stories, locally advanced and metastatic cancer remains incurable. Ideally, new therapies are needed that specifically target cancer cells and derive efficacy by targeting molecular pathways that are unique to distinct tumor profiles and individual patients. Toward this end, we focus on the use of biomimicry to exploit mechanisms by which cancer cells uptake molecular cargo. Naturally, some cancer cells are dependent upon exogenous cholesterol for cellular signaling, growth, and in some cancers, such as prostate, ster...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: McMahon, K. M., Vander Griend, D., Volpert, O., Thaxton, C. S. Tags: Cancer Chemistry Source Type: research

Abstract 313: Examining the role of ABCA1 cholesterol transporter in ovarian cancer spheroids
Epithelial ovarian cancer (EOC) is a devastating disease which accounts for a large proportion of gynaecological cancer-related deaths. Poor survival is largely due to late diagnosis of the disease which typically presents with peritoneal dissemination. In order to achieve reduced tumor burden and improved survival, it is imperative to identify new prognostic markers and potential therapeutic targets. Recent work by our group identified high ATP- Binding Cassette A1 (ABCA1) transporter expression as being associated with poor outcome in EOC. ABCA1 has been widely studied as a cholesterol transporter, however there is littl...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Williams, R., Russell, A., Bongers, A., Sagnella, S., Fife, C., Jessup, W., DeFazio, A., Chenevix-Trench, G., Haber, M., Norris, M., Henderson, M. Tags: Tumor Biology Source Type: research

Abstract 5418: Tumor-targeted nanoparticle delivery of HuR-RNAi suppresses lung cancer cell proliferation and cell migration
Conclusions. Tumor-targeted nanoparticle delivery of HuR-RNAi in lung cancer cells selectively inhibited HuR and HuR-regulated oncoproteins resulting in diminished cell proliferation and cell migration in vitro. Acknowledgement. This study was funded by a grant (R01CA167516-01) from the National Cancer Institute. Citation Format: Ranganayaki Muralidharan, Anish Babu, Kanthesh Basalingappa, Anupama Munshi, Rajagopal Ramesh. Tumor-targeted nanoparticle delivery of HuR-RNAi suppresses lung cancer cell proliferation and cell migration. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Canc...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Muralidharan, R., Babu, A., Basalingappa, K., Munshi, A., Ramesh, R. Tags: Cancer Chemistry Source Type: research