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Source: Molecular Carcinogenesis
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Total 68 results found since Jan 2013.
Copy number variation, increased gene expression, and molecular mechanisms of neurofascin in lung cancer
This study aimed at increasing the knowledge on the involvement of adhesion molecules in lung cancer progression by studying the regulation and role of NFASC in non‐small cell lung cancer (NSCLC). Here, copy number variations in the NFASC gene were analyzed in tumor and non‐tumorous lung tissues of 204 NSCLC patients. Frequent gene amplifications (OR = 4.50, 95%CI: 2.27‐8.92, P ≤ 0.001) and increased expression of NFASC (P = 0.034) were identified in tumors of NSCLC patients. Furthermore, molecular mechanisms of NFASC in lung cancer progression were evaluated by investigating the effects of NFASC silenc...
Source: Molecular Carcinogenesis - May 2, 2017 Category: Molecular Biology Authors: Johanna Samulin Erdem, Yke Jildouw Arnoldussen, Vidar Skaug, Aage Haugen, Shanbeh Zienolddiny Tags: RESEARCH ARTICLE Source Type: research
UCP2 Upregulation Promotes PLC γ‐1 Signaling During Skin Cell Transformation
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Source: Molecular Carcinogenesis - June 1, 2017 Category: Molecular Biology Authors: Annapoorna Sreedhar, Julia Lefort, Petra Petruska, Xin Gu, Runhua Shi, Sumitra Miriyala, Manikandan Panchatcharam, Yunfeng Zhao Tags: RESEARCH ARTICLE Source Type: research
Inhibition of Glycogen Synthase Kinase 3 beta (GSK3 β) Suppresses the Progression of Esophageal Squamous Cell Carcinoma by Modifying STAT3 Activity
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Source: Molecular Carcinogenesis - June 2, 2017 Category: Molecular Biology Authors: Shegan Gao, Shuoguo Li, Xiaoxian Duan, Zhen Gu, Zhikun Ma, Xiang Yuan, Xiaoshan Feng, Huizhi Wang Tags: RESEARCH ARTICLE Source Type: research
CCL20 promotes migration and invasiveness of human cancerous breast epithelial cells in primary culture
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Source: Molecular Carcinogenesis - June 15, 2017 Category: Molecular Biology Authors: Antonella Muscella, Carla Vetrugno, Santo Marsigliante Tags: RESEARCH ARTICLE Source Type: research
Lasp2 enhances tumor invasion via facilitating phosphorylation of FAK and predicts poor overall survival of non ‐small cell lung cancer patients
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Source: Molecular Carcinogenesis - July 1, 2017 Category: Molecular Biology Authors: Xiupeng Zhang, Lin Cai, Haijing Zhou, Yang Liu, Chuifeng Fan, Liang Wang, Ailin Li, Yuan Miao, Qingchang Li, Xueshan Qiu, Enhua Wang Tags: RESEARCH ARTICLE Source Type: research
p0071 interacts with E ‐cadherin in the cytoplasm so as to promote the invasion and metastasis of non‐small cell lung cancer
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Source: Molecular Carcinogenesis - September 12, 2017 Category: Molecular Biology Authors: Huanyu Zhao, Di Zhang, Lianhe Yang, Enhua Wang Tags: RESEARCH ARTICLE Source Type: research
Metabolite of ellagitannins, urolithin A induces autophagy and inhibits metastasis in human sw620 colorectal cancer cells
This study found that submicromolar concentrations of urolithin A, a major polyphenol metabolite, induced autophagy in SW620 colorectal cancer (CRC) cells. Exposure to urolithin A also dose‐dependently decreased cell proliferation, delayed cell migration and decreased matrix metalloproteinas‐9 (MMP‐9) activity. In addition, inhibition of autophagy by Atg5‐siRNA, caspases by Z‐VAD‐FMK suppressed urolithin A‐ stimulated cell death and anti‐metastatic effects. Micromolar urolithin A concentrations induced both autophagy and apoptosis. Urolithin A suppressed cell cycle progression and inhibited DNA synthesis. T...
Source: Molecular Carcinogenesis - October 4, 2017 Category: Molecular Biology Authors: Wenhua Zhao, Fengqiang Shi, Zhikun Guo, Jiaojie Zhao, Xueying Song, Hua Yang Tags: RESEARCH ARTICLE Source Type: research
Pro ‐inflammatory M1 Macrophage enhances metastatic potential of ovarian cancer cells through NF‐κB activation
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Source: Molecular Carcinogenesis - October 12, 2017 Category: Molecular Biology Authors: Untack Cho, Boyun Kim, Soochi Kim, Youngjin Han, Yong Sang Song Tags: RESEARCH ARTICLE Source Type: research
