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Suppression of PGE2/EP2 signaling alleviates Hirschsprung disease by upregulating p38 mitogen-activated protein kinase activity
In this study, anEdnrb-deficient mouse model of HSCR was generated and used to investigate if PGE2/EP2 pathway could be a potential therapeutic target for HSCR. We found that downregulation of PGE2/EP2 signaling by siRNA-mediated ablation of a PGE2 synthase or pharmacologic blockage of EP2 enhanced ENCC colonization in the distal bowel ofEdnrb−/− mice and alleviated their HSCR-like symptoms. Furthermore, blockage of EP2 was shown to promote ENCC migration through upregulating p38 mitogen-activated protein kinase activity, which was downregulated in the colon ofEdnrb−/− mice and in the distal aganglionic bowel of HS...
Source: Journal of Molecular Medicine - July 31, 2023 Category: Molecular Biology Source Type: research

MicroRNA-145 targets Smad1 in endometrial stromal cells and regulates decidualization in rat
In conclusion, the study demonstrated the role of miR-145 in regulation of progression of decidualization which is mediated through inhibition of Smad1.Key messagesMiR-145 expression is downregulated during decidualization in the rat uterus.Overexpression of miR-145 inhibited the decidualization progression.MiR-145 suppressed the migration and invasion of HUVECs.MiR-145 downregulated Smad1 which suppresses Smad1/5/8, Wnt-4, MMP-9, Cox-2, and VEGF.
Source: Journal of Molecular Medicine - February 7, 2019 Category: Molecular Biology Source Type: research