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Abstract B37: The histone deacetylase inhibitor panobinostat sensitizes cyclin E-amplified ovarian cancer cells to poly ADP ribose polymerase inhibitors via E2F1 downregulation.
Conclusions: The development of a new PARPi combination therapy with panobinostat has immediate prospects for rapid translation to the clinic and great potential for improving clinical outcomes for non-BRCAness, chemoresistant ovarian cancer.Citation Format: Andrew J. Wilson, Jeanette Saskowski, Dineo Khabele. The histone deacetylase inhibitor panobinostat sensitizes cyclin E-amplified ovarian cancer cells to poly ADP ribose polymerase inhibitors via E2F1 downregulation.. [abstract]. In: Proceedings of the AACR Special Conference on Chromatin and Epigenetics in Cancer; Sep 24-27, 2015; Atlanta, GA. Philadelphia (PA): AACR;...
Source: Cancer Research - January 14, 2016 Category: Cancer & Oncology Authors: Wilson, A. J., Saskowski, J., Khabele, D. Tags: Epigenetic Cancer Therapies Source Type: research

Abstract 971: Phosphatase PTP4A3 is critical for cell growth of triple-negative breast cancer
Conclusion: These studies identified a set of highly expressed phosphatases that represent promising targets for the treatment of TNBCs. We also demonstrated that one of these phosphatases, PTP4A3, is critical for the growth of TNBCs in vitro and in vivo, and PTP4A3 expression is prognostic in women with TNBC. These results provide the rationale for further study of growth promoting phosphatases and suggest that such phosphatases may be targeted for the treatment of this aggressive form of breast cancer. Research supported by: Susan G. Komen for the Cure (PB, GM), Komen SAB, and the Norman Brinker Award for Research Excell...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Hollander, P. d., Tismelzon, A., Shepherd, J., Rawls, K. R., Hill, J. L., Mazumdar, A., Hilsenbeck, S. G., Mills, G. B., Brown, P. H. Tags: Molecular and Cellular Biology Source Type: research