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Abstract B26: PI3K class I and mTOR regulate distinct steps in Met dependent tumorigenesis
The Receptor Tyrosine Kinase (RTK) Met, overexpressed or mutated in cancer, plays a major role in cancer progression and represents an attractive target for cancer therapy. Although several Met inhibitors are in clinical trials, resistance may occur as experienced in the clinic with other RTKs. Thus, a need for alternative / complementary therapy may be required to target Met driven tumors efficiently.The aim of this study was to investigate whether PI3K plays a role in Met oncogenic activity, in view of designing appropriate therapy.The study was performed on two cell models suitable to study Met driven NIH3T3 cells expre...
Source: Molecular Cancer Therapeutics - July 6, 2015 Category: Cancer & Oncology Authors: Hervieu, A., Kermorgant, S. Tags: PI3K-mTOR Activation in Human Cancer: Poster Presentations - Proffered Abstracts Source Type: research
