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Melatonin activates the Mst1-Nrf2 signaling to alleviate cardiac hypertrophy in pulmonary arterial hypertension
This study aims to suggest one such possible treatment, through investigating the cardio-protective capabilities of the anti-oxidant, melatonin (Mel), for treating adverse RV remodeling in PAH, along with its underlying mechanisms. Arginine vasopressin induced neonatal rat cardiomyocyte hypertrophy in vitro; in vivo, PAH was induced in rats through intraperitoneal monocrotaline (MCT) injections, and Mel was administered intraperitoneally 24 h prior to MCT. Mel reduced rat cardiomyocyte hypertrophy and mitochondrial oxidative stress in vitro by activating the Mst1-Nrf2 pathway, which were all reversed upon siRNA knockdown o...
Source: European Journal of Pharmacology - September 13, 2022 Category: Drugs & Pharmacology Authors: Shuang Chen Ping Sun You Li Wenqian Shen Chao Wang Peng Zhao Hao Cui Jing-Yi Xue Guo-Qing Du Source Type: research

Melatonin Postconditioning Ameliorates Anoxia/Reoxygenation Injury by Regulating Mitophagy and Mitochondrial Dynamics in a SIRT3-Dependent Manner
Eur J Pharmacol. 2021 May 7:174157. doi: 10.1016/j.ejphar.2021.174157. Online ahead of print.ABSTRACTIschaemia/reperfusion (I/R) injury is accompanied by excessive mitochondrial autophagy (mitophagy) and an imbalance in mitochondrial dynamics. Melatonin has been reported to alleviate I/R injury by regulating mitophagy and mitochondrial dynamics. However, the underlying mechanism associated with this activity is not fully understood. The goal of the present study was to investigate whether and how melatonin administration at the beginning of reoxygenation exerts protective effects by regulating mitophagy and mitochondrial d...
Source: European Journal of Pharmacology - May 10, 2021 Category: Drugs & Pharmacology Authors: Yang Bai Yanli Yang Yafen Gao Duomao Lin Zhaoqi Wang Jun Ma Source Type: research

SIRT1 inhibition by melatonin exerts antitumor activity in human osteosarcoma cells.
In this study, we assessed the antitumor activity of melatonin against human osteosarcoma cells (9607 cell line) and explored the role of SIRT1 in the activity of melatonin. melatonin treatment resulted in strong antitumor activity, as evidenced not only by reductions in tumor cell vitality, adhesion ability, migration ability and glutathione (GSH) levels but also by increases in the apoptotic index and reactive oxygen species. Additionally, melatonin treatment down-regulated SIRT1 and up-regulated acetylated-p53. Sirtinol (a known SIRT1 inhibitor) and SIRT1 siRNA further enhanced the antitumor activity of melatonin, while...
Source: European Journal of Pharmacology - May 29, 2013 Category: Drugs & Pharmacology Authors: Cheng Y, Cai L, Jiang P, Wang J, Gao C, Feng H, Wang C, Pan H, Yang Y Tags: Eur J Pharmacol Source Type: research