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Source: Journal of Neuroscience Research
Drug: Simvastatin
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Total 1 results found since Jan 2013.
Simvastatin prevents neuroinflammation by inhibiting N‐methyl‐D‐aspartic acid receptor 1 in 6‐hydroxydopamine‐treated PC12 cells
This study investigates the impact of simvastatin on neuroinflammation in experimental parkinsonian cell models. 6‐Hydroxydopamine (6‐OHDA)‐treated pheochromocytoma‐12 (PC12) cells were used to investigate the neuroprotective nature of simvastatin. After incubation with 6‐OHDA, simvastatin, and/or N‐methyl‐D‐aspartic acid receptor 1 (NMDAR1) siRNA for 24 hr, test kits were used to detect the levels of lactate dehydrogenase (LDH) and glutamate released from PC12 cells exposed to different culture media. The mRNA levels of tumor necrosis factor (TNF)‐α, interleukin (IL)−1β, and IL‐6 were determined by...
Source: Journal of Neuroscience Research - January 31, 2014 Category: Neuroscience Authors: Junqiang Yan, Jiachun Sun, Lina Huang, Qizhi Fu, Ganqin Du Tags: Research Article Source Type: research
