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Transcriptional Regulation of NHE3 and SGLT1 by the Circadian Clock Protein Per1 in Proximal Tubule Cells.
Abstract We have previously demonstrated that the circadian clock protein Per1 coordinately regulates multiple genes involved in sodium reabsorption in renal collecting duct cells. Consistent with these results, Per1 KO mice exhibit dramatically lower blood pressure than WT mice. The proximal tubule is responsible for a majority of sodium reabsorption. Previous work has demonstrated that expression of the sodium hydrogen exchanger NHE3 oscillates with a circadian pattern and SGLT1 has been demonstrated to be a circadian target in the colon, but whether these target genes are regulated by Per1 has not been investig...
Source: American Journal of Physiology. Renal Physiology - September 16, 2015 Category: Physiology Authors: Solocinski K, Richards J, All SC, Cheng KY, Khundmiri SJ, Gumz ML Tags: Am J Physiol Renal Physiol Source Type: research