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AT1 Receptors in the Subfornical Organ Modulate Arterial Pressure and the Baroreflex In Two-kidney One-clip Hypertensive Rats.
Abstract The subfornical organ (SFO), a forebrain circumventricular organ that lies outside the blood brain barrier, has been implicated in arterial pressure and baroreflex responses to angiotensin II (Ang II). We tested whether pharmacologic inhibition or selective silencing of SFO AT1 receptors (AT1R) of two-kidney one-clip rats with elevated plasma Ang II decreases resting arterial pressure and renal sympathetic nerve activity (RSNA) and/or modulates arterial baroreflex responses of heart rate and RSNA. Male Sprague Dawley rats underwent renal artery clipping (2K-1C) or sham-clipping (Sham). Six weeks later, co...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - January 9, 2019 Category: Physiology Authors: Rossi NF, Zenner Z, Rishi AK, Levi E, Maliszewska-Scislo M Tags: Am J Physiol Regul Integr Comp Physiol Source Type: research

Angiotensin II regulates brain (pro)renin receptor expression through activation of cAMP response element-binding protein.
We reported that brain (pro)renin receptor (PRR) expression levels are elevated in deoxycorticosterone acetate (DOCA)-salt-induced hypertension; however, the underlying mechanism remained unknown. To address whether angiotensin (Ang II) type 1 receptor (AT1R) signaling is involved in this regulation, we implanted a DOCA pellet and supplying 0.9% saline as the drinking solution to C57BL/6J mice; SHAM pellet-implanted mice provided regular drinking water served as controls. Concurrently, mice were intracerebroventricularly (ICV) infused with the AT1R blocker losartan, angiotensin converting-enzyme inhibitor captopril, or art...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - May 20, 2015 Category: Physiology Authors: Li W, Liu J, Hammond SL, Tjalkens RB, Saifudeen Z, Feng Y Tags: Am J Physiol Regul Integr Comp Physiol Source Type: research