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Specialty: Toxicology
Condition: Benign Prostatic Hyperplasia
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Total 1 results found since Jan 2013.
Role of connexin 43 in cadmium ‐induced proliferation of human prostate epithelial cells
In this study, the human prostate epithelial cell line RWPE‐1 was exposed to Cd. A low dose of Cd stimulated cell proliferation along with a lower degree of gap junction intercellular communication and an elevated level of the protein Cx43. Cd exposure increased the levels of intracellular Ca2+ and phosphorylated Cx43 at the Ser368 site. Knockdown of Cx43 using siRNA blocked Cd‐induced proliferation and interfered with the Cd‐induced changes in the protein levels of cyclin D1, cyclin B1, p27Kip1 (p27) and p21Waf1/Cip1 (p21). The increase in Cx43 expression induced by Cd was presumably mediated by the androgen recepto...
Source: Journal of Applied Toxicology - February 7, 2017 Category: Toxicology Authors: Qingping Liu, Xiaoli Ji, Zehe Ge, Haipeng Diao, Xiuli Chang, Lihua Wang, Qing Wu Tags: Research article Source Type: research
