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TRAF6 regulates proliferation of stromal cells in the transition and peripheral zones of benign prostatic hyperplasia via Akt/mTOR signaling
ConclusionsTRAF6 can promote the proliferation of stromal cells of BPH via Akt/mTOR signaling. Our results may make stromal TRAF6 responsible for zonal characteristic of BPH and as a promising therapeutic strategy for BPH treatment.
Source: The Prostate - November 24, 2017 Category: Urology & Nephrology Authors: Yun ‐Feng Shi, Dian‐Jun Yu, Chen‐Yi Jiang, Xing‐Jie Wang, Yi‐Ping Zhu, Rui‐Zhe Zhao, Zhong Lv, Xiao‐Wen Sun Tags: ORIGINAL ARTICLE Source Type: research

Simvastatin Up ‐Regulates Annexin A10 That Can Inhibit the Proliferation, Migration, and Invasion in Androgen‐Independent Human Prostate Cancer Cells
CONCLUSIONOur results suggest that statins inhibit the proliferation, migration, and invasion of androgen‐independent prostate cancer cells by up‐regulation of ANXA10. Additionally, it is possible that S100A4 plays a role in these effects. Statins may be beneficial in the prevention and/or treatment of prostate cancer. Prostate © 2016 Wiley Periodicals, Inc.
Source: The Prostate - November 7, 2016 Category: Urology & Nephrology Authors: Yoshiyuki Miyazawa, Yoshitaka Sekine, Haruo Kato, Yosuke Furuya, Hidekazu Koike, Kazuhiro Suzuki Tags: Original Article Source Type: research

The over‐expression of Pim‐2 promote the tumorigenesis of prostatic carcinoma through phosphorylating eIF4B
CONCLUSIONPim‐2 was over‐expressed in PCA cell lines and tissues. It may inhibit the apoptosis of PCA cells through phosphorylating eIF4B, thus promote the tumorigenesis of PCA. Prostate © 2013 Wiley Periodicals, Inc.
Source: The Prostate - June 27, 2013 Category: Urology & Nephrology Authors: Ke Ren, Xin Gou, Mingzhao Xiao, Ming Wang, Chaodong Liu, Zhaobing Tang, Weiyang He Tags: Original Article Source Type: research