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MELK Decreases Replication Stress Cell Biology
Maternal embryonic leucine zipper kinase (MELK) belongs to the subfamily of AMP-activated Ser/Thr protein kinases. The expression of MELK is very high in glioblastoma-type brain tumors, but it is not clear how this contributes to tumor growth. Here we show that the siRNA-mediated loss of MELK in U87 MG glioblastoma cells causes a G1/S phase cell cycle arrest accompanied by cell death or a senescence-like phenotype that can be rescued by the expression of siRNA-resistant MELK. This cell cycle arrest is mediated by an increased expression of p21WAF1/CIP1, an inhibitor of cyclin-dependent kinases, and is associated with the h...
Source: Journal of Biological Chemistry - August 16, 2013 Category: Chemistry Authors: Kig, C., Beullens, M., Beke, L., Van Eynde, A., Linders, J. T., Brehmer, D., Bollen, M. Tags: Signal Transduction Source Type: research