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Source: Trends in Genetics : TIG
Condition: ALS
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Total 3 results found since Jan 2013.
Repetitive elements in aging and neurodegeneration
Trends Genet. 2023 Mar 17:S0168-9525(23)00034-3. doi: 10.1016/j.tig.2023.02.008. Online ahead of print.ABSTRACTRepetitive elements (REs), such as transposable elements (TEs) and satellites, comprise much of the genome. Here, we review how TEs and (peri)centromeric satellite DNA may contribute to aging and neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS). Alterations in RE expression, retrotransposition, and chromatin microenvironment may shorten lifespan, elicit neurodegeneration, and impair memory and movement. REs may cause these phenotypes via DNA damage, protein sequestration, insertional muta...
Source: Trends in Genetics : TIG - March 19, 2023 Category: Genetics & Stem Cells Authors: Katie E Copley James Shorter Source Type: research
