Filtered By:
Specialty: Science
Condition: Sleep Disorders
This page shows you your search results in order of date.
Order by Relevance | Date
Total 1 results found since Jan 2013.
Melanopsin Signaling Pathway in HEK293 Cell Line with Stable Expression of Human Melanopsin: Possible Participation of Phospholipase C beta 4 and Diacylglycerol
AbstractMelanopsin, a member of the G-protein coupled receptors family, is involved in non-image-forming functions including circadian rhythm, sleep regulation, pupil response. In spite of significant research efforts, the signaling cascade involving melanopsin photoactivation remains poorly characterized. Here, we analyzed the effects of photoactivation of melanopsin on phospholipase C (PLC) and diacylglycerol. As anin vitro model, HEK293 cells with stable expression of human melanopsin were used. Although both the PLCβ1 and PLCβ4 subtypes were activated by the cell exposure to blue light, only PLCβ4 appeared to play a...
Source: Photochemistry and Photobiology - May 12, 2021 Category: Science Authors: Olga I. Krzysztynska ‐Kuleta,
Magdalena M. Olchawa,
Tadeusz J. Sarna Tags: RESEARCH ARTICLE Source Type: research
