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Abstract 537: Toll-like receptor (TLR3) signaling in human hepatocellular carcinoma (HCC) depends on the tumor-associated long-noncoding RNA H19
HCC is the third leading cause of cancer-related mortality worldwide. Metabolic syndrome diseases are shown to facilitate the progression of HCC in industrial countries. Recent studies unraveled pivotal roles of long non-coding RNAs (lncRNAs) in carcinogenesis and cancer metastasis. The controversy that the non-translated H19 mRNA harbors pro- as well as anti-tumorigenic potential shows that its function is poorly characterized. TLR3 plays a key role in the recognition of exogenous pathogen-associated dsRNA and even more importantly TLR3 is activated by endogenous injury-associated ligands. There is increasing evidence tha...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Paulus, P., Urbschat, A., Reissig, C., Zacharowski, K., Drose, S., Scheller, B., Tybl, E. Tags: Molecular and Cellular Biology Source Type: research

Abstract 2270: TRAIL-TZD combinatorial treatment induces apoptosis in prostate cancer cells through modulation of AMPK signaling pathway
In this study we determined AMP-activated protein kinase (AMPK) as a potential target for TRAIL-TZD-induced apoptosis in prostate cancer cells. AMPK is a family of serine/threonine protein kinase and is highly conserved from yeast to human. It consists of three subunits: a catalytic α subunit and regulatory β and γ subunits. AMPK is a well-accepted target for the treatment of metabolic syndrome and Type 2 diabetes. We used C42-DN (stably overexpressing AMPK α1-dominant negative) and C42-EV (empty vector) prostate cancer cell lines to study differences in TRAIL-TZD-induced apoptosis. Our studies showed a dose dependent ...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Santha, S., Majumdar, S., Viswakarma, N., Rana, A., Rana, B. Tags: Molecular and Cellular Biology Source Type: research