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Condition: Faconi Anemia
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Total 16 results found since Jan 2013.
Non-erythroid alpha spectrin prevents telomere dysfunction after DNA interstrand cross-link damage
Telomere integrity is critical for telomere function and genomic stability. We previously demonstrated that non-erythroid α-spectrin (αIISp) is present in mammalian cell nuclei where it is important in repair of DNA interstrand cross-links (ICLs) and chromosome stability. We now demonstrate that αIISp is also important for telomere maintenance after ICL damage. It localizes to telomeres in S phase after ICL damage where it has enhanced association with TRF1 and TRF2 and is required for recruitment of the ICL repair protein, XPF, to damage-induced foci at telomeres. In telomerase-positive normal cells depl...
Source: Nucleic Acids Research - May 27, 2013 Category: Research Authors: Zhang, P., Herbig, U., Coffman, F., Lambert, M. W. Tags: Genome Integrity, Repair and Replication Source Type: research
