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The antidepressant- and anxiolytic-like effects of resveratrol: Involvement of phosphodiesterase-4D inhibition.
Abstract Resveratrol is a natural non-flavonoid polyphenol found in red wine, which has numerous pharmacological properties including anti-stress and antidepressant-like abilities. However, whether the antidepressant- and anxiolytic-like effects of resveratrol are related to the inhibition of phosphodiesterase 4 (PDE4) and its subtypes remains unknown. The same holds true for the subsequent cAMP-dependent pathway. The first set of studies investigated whether resveratrol exhibited neuroprotective effects against corticosterone-induced cell lesion as well as its underlying mechanism. We found that 100 μM cortico...
Source: Neuropharmacology - April 22, 2019 Category: Drugs & Pharmacology Authors: Zhu X, Li W, Li Y, Xu W, Yuan Y, Zheng V, Zhang HT, O'Donnell JM, Xu Y, Yin X Tags: Neuropharmacology Source Type: research