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The antidepressant- and anxiolytic-like effects of resveratrol: Involvement of phosphodiesterase-4D inhibition.
Abstract Resveratrol is a natural non-flavonoid polyphenol found in red wine, which has numerous pharmacological properties including anti-stress and antidepressant-like abilities. However, whether the antidepressant- and anxiolytic-like effects of resveratrol are related to the inhibition of phosphodiesterase 4 (PDE4) and its subtypes remains unknown. The same holds true for the subsequent cAMP-dependent pathway. The first set of studies investigated whether resveratrol exhibited neuroprotective effects against corticosterone-induced cell lesion as well as its underlying mechanism. We found that 100 μM cortico...
Source: Neuropharmacology - April 22, 2019 Category: Drugs & Pharmacology Authors: Zhu X, Li W, Li Y, Xu W, Yuan Y, Zheng V, Zhang HT, O'Donnell JM, Xu Y, Yin X Tags: Neuropharmacology Source Type: research

Inhibition of phosphodiesterase 2 reverses gp91phox oxidase-mediated depression- and anxiety-like behavior.
Abstract Phosphodiesterase 2 (PDE2) plays an important role in treatment of stress-related depression through regulation of antioxidant defense and neuroprotective mechanisms. However, the causal relationship between PDE2 and the prevalence of depression and anxiety upon exposure to oxidative stress has not been investigated. The present study examined whether the effects of PDE2 inhibition on oxidative stress were directly involved in reduced ROS by regulating NADPH subunits gp91phox oxidase. The results suggested that the PDE2 inhibitor Bay 60-7550 reversed oxidative stress-induced behavioral signature, i.e. dep...
Source: Neuropharmacology - September 27, 2018 Category: Drugs & Pharmacology Authors: Huang X, Xiaokaiti Y, Yang J, Pan J, Li Z, Luria V, Li Y, Song G, Zhu X, Zhang HT, O'Donnell JM, Xu Y Tags: Neuropharmacology Source Type: research