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Microsomal PGE2 synthase‐1 regulates melanoma cell survival and associates with melanoma disease progression
This article is protected by copyright. All rights reserved.
Source: Pigment Cell Research - January 23, 2016 Category: Cytology Authors: Sun‐Hee Kim, Yuuri Hashimoto, Sung‐Nam Cho, Jason Roszik, Denái R. Milton, Fulya Dal, Sangwon F. Kim, David G. Menter, Peiying Yang, Suhendan Ekmekcioglu, Elizabeth A. Grimm Tags: Original Article Source Type: research

Brain metastasis is predetermined in early stages of cutaneous melanoma by CD44v6 expression through epigenetic regulation of the spliceosome
Summary Melanoma brain metastasis (MBM) is frequent and has a very poor prognosis with no current predictive factors or therapeutic molecular targets. Our study unravels the molecular alterations of cell‐surface glycoprotein CD44 variants during melanoma progression to MBM. High expression of CD44 splicing variant 6 (CD44v6) in primary melanoma (PRM) and regional lymph node metastases from AJCC Stage IIIC patients significantly predicts MBM development. The expression of CD44v6 also enhances the migration of MBM cells by hyaluronic acid and hepatocyte growth factor exposure. Additionally, CD44v6‐positive MBM migration ...
Source: Pigment Cell Research - September 30, 2014 Category: Cytology Authors: Diego M. Marzese, Michelle Liu, Jamie L. Huynh, Hajime Hirose, Nicholas C. Donovan, Kelly T. Huynh, Eiji Kiyohara, Kelly Chong, David Cheng, Ryo Tanaka, Jinhua Wang, Donald L. Morton, Garni Barkhoudarian, Daniel F. Kelly, Dave S. B. Hoon Tags: Original Article Source Type: research

Brain Metastasis is Predetermined in Early‐Stages of Cutaneous Melanoma by CD44v6 Expression through Epigenetic Regulation of the Spliceosome
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Source: Pigment Cell Research - August 28, 2014 Category: Cytology Authors: Diego M. Marzese, Michelle Liu, Jamie L. Huynh, Hajime Hirose, Nicholas C. Donovan, Kelly T. Huynh, Eiji Kiyohara, Kelly Chong, David Cheng, Ryo Tanaka, Jinhua Wang, Donald L. Morton, Garni Barkhoudarian, Daniel F. Kelly, Dave S.B. Hoon Tags: Original Article Source Type: research

Control of NF‐kB activity in human melanoma by bromodomain and extra‐terminal protein inhibitor I‐BET151
In this study, we have examined the ability of the bromodomain and extra‐terminal (BET) protein inhibitor I‐BET151 to inhibit NF‐kB in melanoma cells. We show that I‐BET151 is a potent, selective inhibitor of a number of NF‐kB target genes involved in induction of inflammation and cell cycle regulation and downregulates production of cytokines such as IL‐6 and IL‐8. SiRNA studies indicate that BRD2 is the main BET protein involved in regulation of NF‐kB and that I‐BET151 caused transcriptional downregulation of the NF‐kB subunit p105/p50. These results suggest that BET inhibitors may have an important r...
Source: Pigment Cell Research - July 3, 2014 Category: Cytology Authors: Stuart J. Gallagher, Branka Mijatov, Dilini Gunatilake, Kavitha Gowrishankar, Jessamy Tiffen, Wilmott James, Lei Jin, Gulietta Pupo, Carleen Cullinane, Grant A. McArthur, Peter J. Tummino, Helen Rizos, Peter Hersey Tags: Original Article Source Type: research

Decatenation checkpoint‐defective melanomas are dependent on PI3K for survival
Summary Melanoma cell lines are commonly defective for the G2‐phase cell cycle checkpoint that responds to incomplete catenation of the replicated chromosomes. Here, we demonstrate that melanomas defective for this checkpoint response are less sensitive to genotoxic stress, suggesting that the defective cell lines compensated for the checkpoint loss by increasing their ability to cope with DNA damage. We performed an siRNA kinome screen to identify kinases responsible and identified PI3K pathway components. Checkpoint‐defective cell lines were three‐fold more sensitive to small molecule inhibitors of PI3K. The PI3K i...
Source: Pigment Cell Research - June 23, 2014 Category: Cytology Authors: Kelly Brooks, Max Ranall, Loredana Spoerri, Alex Stevenson, Gency Gunasingh, Sandra Pavey, Fred Meunier, Thomas J. Gonda, Brian Gabrielli Tags: Original Article Source Type: research

Decatenation checkpoint defective melanomas are dependent on PI3K for survival
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Source: Pigment Cell Research - May 29, 2014 Category: Cytology Authors: Kelly Brooks, Max Ranall, Loredana Spoerri, Alex Stevenson, Gency Gunasingh, Sandra Pavey, Fred Meunier, Thomas J Gonda, Brian Gabrielli Tags: Original Article Source Type: research

Control of NF‐kB activity in human melanoma by BET protein inhibitor I‐BET151
This article is protected by copyright. All rights reserved.
Source: Pigment Cell Research - May 1, 2014 Category: Cytology Authors: Stuart John Gallagher, Branka Mijatov, Dilini Gunatilake, Kavitha Gowrishankar, Jessamy Tiffen, Wilmott James, Lei Jin, Gulietta Pupo, Carleen Cullinane, Grant A McArthur, Peter J Tummino, Helen Rizos, Peter Hersey Tags: Original Article Source Type: research

Predicting cell shapes in melanomas
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Source: Pigment Cell Research - October 4, 2013 Category: Cytology Authors: Benjamin J. Tyrrell, Matthew Neilson, Robert H. Insall, Laura M. Machesky Tags: News & Views Source Type: research

Identification of glycogen synthase kinase 3α as a therapeutic target in melanoma
Summary Deregulated expression or activity of kinases can lead to melanomas, but often the particular kinase isoform causing the effect is not well established, making identification and validation of different isoforms regulating disease development especially important. To accomplish this objective, an siRNA screen was undertaken that which identified glycogen synthase kinase 3α (GSK3α) as an important melanoma growth regulator. Melanocytes and melanoma cell lines representing various stages of melanoma tumor progression expressed both GSK3α and GSK3β, but analysis of tumors in patients with melanoma showed elevated ...
Source: Pigment Cell Research - September 19, 2013 Category: Cytology Authors: SubbaRao V. Madhunapantula, Arati Sharma, Raghavendra Gowda, Gavin P. Robertson Tags: Original Article Source Type: research

Identification of Glycogen Synthase Kinase 3α (GSK3α) as a Therapeutic Target In Melanoma
This article is protected by copyright. All rights reserved.
Source: Pigment Cell Research - August 19, 2013 Category: Cytology Authors: SubbaRao V. Madhunapantula, Arati Sharma, Raghavendra Gowda, Gavin P. Robertson Tags: Original Article Source Type: research