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Sulforaphane regulates the proliferation of leukemia stem-like cells via Sonic Hedgehog signaling pathway
This study explored the effects and related molecular mechanisms of SFN on the proliferation of leukemia stem-like cells in acute myeloid leukemia cells. We found that SFN inhibited the proliferation of leukemia stem-like cells in vitro and in vivo. Meanwhile, we observed that SFN could regulate the stem characteristic of leukemia cells. After SFN treatment, the expression of the key players in the Sonic Hedgehog (Shh) signaling pathway was significantly decreased at the transcriptional and protein levels. To further determine the contribution of the Shh signaling molecular mechanism to SFN-mediated self-renewal capability...
Source: European Journal of Pharmacology - February 14, 2022 Category: Drugs & Pharmacology Authors: Fanping Wang Xiaoyu Huang Yanwei Sun Zhixin Li Ruili Sun Tiesuo Zhao Mingyong Wang Chunxia Yan Peijun Liu Source Type: research

Overexpressed mitogen-and stress-activated protein kinase 1 promotes the resistance of cytarabine in acute myeloid leukemia through brahma related gene 1-mediated upregulation of heme oxygenase-1
Eur J Pharmacol. 2021 Dec 22:174722. doi: 10.1016/j.ejphar.2021.174722. Online ahead of print.ABSTRACTDrug resistance remains a major challenge in the current treatment of acute myeloid leukemia (AML). Finding specific molecules responsible for mediating drug resistance in AML contributes to the effective reversal of drug resistance. Recent studies have found that mitogen- and stress-activated protein kinase 1 (MSK1) is of great significance in the occurrence and development of tumors. In the current study, MSK1 was found highly expressed in drug-resistant AML patients. Heme oxygenase-1 (HO-1) has been previously validated...
Source: European Journal of Pharmacology - December 26, 2021 Category: Drugs & Pharmacology Authors: Siyu Zhang Chengyun Pan Qin Shang Weili Wang Tianzhen Hu Ping Liu Siyu Chen Jishi Wang Qin Fang Source Type: research

Bryostatin 5 induces apoptosis in acute monocytic leukemia cells by activating PUMA and caspases.
Abstract Acute leukemia is a malignant clonal hematopoietic stem cell disease. In the current study, we examined the effects of bryostatin 5 on acute monocytic leukemia cells in vitro and in vivo. We also explored the mechanisms and pathways underlying the increase in apoptosis induced by bryostatin 5. Bryostatin 5 inhibited the growth of primary acute monocytic leukemia cells and U937 cells in a dose- and time-dependent manners. Bryostatin 5 also induced an increase in apoptosis and a decrease in the mitochondrial membrane potential (MMP) in U937 cells. Transmission electron microscopy (TEM) revealed that bryosta...
Source: European Journal of Pharmacology - September 11, 2013 Category: Drugs & Pharmacology Authors: Wang Y, Zhang J, Wang Q, Zhang T, Yang Y, Yang F, Gao G, Dong H, Zhu H, Li Y, Lin H, Tang H, Chen X Tags: Eur J Pharmacol Source Type: research