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Source: Biomedical and Environmental Sciences : BES
Cancer: Uveal Melanoma

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p21 is Responsible for Ionizing Radiation-induced Bypass of Mitosis.
CONCLUSION: Our results indicated that p21 was responsible for the downregulation of G2/M transition regulatory proteins and the bypass of mitosis induced by irradiation. Downregulation of p21 by siRNA resulted in G2-arrested cells entering into mitosis with serious DNA damage. This is the first report on elucidating the role of p21 in the bypass of mitosis. PMID: 27554118 [PubMed - in process]
Source: Biomedical and Environmental Sciences : BES - June 30, 2016 Category: Biomedical Science Authors: Zhang XR, Liu YA, Sun F, Li H, Lei SW, Wang JF Tags: Biomed Environ Sci Source Type: research