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Identification of upregulated phosphoinositide 3-kinase γ as a target to suppress breast cancer cell migration and invasion.
Abstract Metastasis is the major cause of breast cancer mortality. We recently reported that aberrant G-protein coupled receptor (GPCR) signaling promotes breast cancer metastasis by enhancing cancer cell migration and invasion. Phosphatidylinositol 3-kinase γ (PI3Kγ) is specifically activated by GPCRs. The goal of the present study was to determine the role of PI3Kγ in breast cancer cell migration and invasion. Immunohistochemical staining showed that the expression of PI3Kγ protein was significantly increased in invasive human breast carcinoma when compared to adjacent benign breast tissue or ductal carcinom...
Source: Biochemical Pharmacology - May 15, 2013 Category: Drugs & Pharmacology Authors: Xie Y, Abel PW, Kirui JK, Deng C, Sharma P, Wolff DW, Toews ML, Tu Y Tags: Biochem Pharmacol Source Type: research

ADAM12 is expressed in the tumour vasculature and mediates ectodomain shedding of several membrane-anchored endothelial proteins
In conclusion, our data demonstrate a role for ADAM12 in ectodomain shedding of several membrane-anchored endothelial proteins. We speculate that this process may have importance in tumour neovascularization or/and tumour-cell extravasation.
Source: BJ Cell - March 5, 2013 Category: Biochemistry Authors: C Fröhlich, M Klitgaard, J B Noer, A Kotzsch, C Nehammer, P Kronqvist, J Berthelsen, C Blobel, M Kveiborg, R Albrechtsen, U M Wewer Tags: BJ Cell Source Type: research

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