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Source: Molecular Cancer Therapeutics
Cancer: Inflammatory Breast Cancer
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Genome and Immune Profiling of Inflammatory Breast Cancer
Inflammatory breast cancer (IBC) is a rare and aggressive form of breast cancer that remains poorly understood at the molecular level. Comprehensive tumor profiling was performed to understand clinically actionable alterations in IBC. Targeted next-generation sequencing (NGS) and IHC were performed to identify activated pathways in IBC tumor tissues. siRNA studies examined the impact of IBC genomic variants in cellular models. IBC tumor tissues were further characterized for immune infiltration and immune checkpoint expression by IHC. Genomic analysis identified recurrent alterations in core biologic pathways, including ac...
Source: Molecular Cancer Therapeutics - July 4, 2016 Category: Cancer & Oncology Authors: Hamm, C. A., Moran, D., Rao, K., Trusk, P. B., Pry, K., Sausen, M., Jones, S., Velculescu, V. E., Cristofanilli, M., Bacus, S. Tags: Companion Diagnostics and Cancer Biomarkers Source Type: research
