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Specialty: Laboratory Medicine
Cancer: Bone Cancers
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Total 34 results found since Jan 2013.
ZBTB7C m6A modification incurred by METTL3 aberration promotes osteosarcoma progression
Transl Res. 2023 Apr 28:S1931-5244(23)00072-5. doi: 10.1016/j.trsl.2023.04.005. Online ahead of print.ABSTRACTAberrant N6-methyladenosine (m6A) modification of mRNAs contributes significantly to the epigenetic tumorigenesis, however, its precise role and the key targets in osteosarcoma (OS) are not defined. Here we reported that selective METTL3 (methyltransferase like 3) elevation and the consequential increase of m6A modification causally affect OS progression. The fast-growing OS cells displayed preferential upregulation of METTL3 and increased m6A modification. Conversely, m6A inhibition by 3-deazaadenosine, siRNA-medi...
Source: Translational Research : the journal of laboratory and clinical medicine - April 30, 2023 Category: Laboratory Medicine Authors: Xueying An Wenshu Wu Lin Yang Jian Dong Bin Liu Junxia Guo Jianmei Chen Baosheng Guo Wangsen Cao Qing Jiang Source Type: research
