Filtered By:
Cancer: Bone Cancers
Management: Funding
This page shows you your search results in order of date.
Order by Relevance | Date
Total 1 results found since Jan 2013.
Abstract 2953: Rev-erb{alpha} modulates Myc-driven cancer cell growth and altered metabolism
Circadian rhythms are regulated by feedback loops comprising a network of factors that regulate Clock-associated genes. Chronotherapy seeks to take advantage of altered circadian rhythms in some cancers to better time administration of treatments to increase efficacy and reduce toxicity. While many cancers have perturbed expression of core circadian rhythm genes, the molecular basis underlying these perturbations and their functional implications in oncogenesis are still poorly understood, and so it is impossible to predict which cancers have altered circadian rhythms and would best benefit from chronotherapy. We have obse...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Altman, B. J., Hsieh, A., Gouw, A. M., Stine, Z. E., Venkataraman, A., Bellovin, D. I., Diskin, S. J., Lu, W., Zhang, S., Felsher, D. W., Maris, J. M., Lazar, M. A., Rabinowitz, J. D., Hogenesch, J. B., Dang, C. V. Tags: Molecular and Cellular Biology Source Type: research
