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RON confers lapatinib resistance in HER2-positive breast cancer cells
Highlights: Abstract: Lapatinib-resistance is a major problem for HER2-positive breast cancer treatment. SK-BR-3-LR, a lapatinib-resistant cell clone, was established from HER2-positive SK-BR-3 breast cancer cells following chronic exposure to lapatinib. The PI3K/AKT signaling pathway was demonstrated to be resistant to HER2 inhibition in SK-BR-3-LR cells. However, both small-molecular Recepteur d’Origine Nantais (RON) inhibitors and RON-targeted small interfering RNA (siRNA) effectively restored lapatinib sensitivity in these cells by inhibiting PI3K/AKT activation. Our results demonstrate for the first time the importa...
Source: Cancer Letters - July 15, 2013 Category: Cancer & Oncology Authors: Quanren Wang, Haitian Quan, Jie Zhao, Chengying Xie, Lei Wang, Liguang Lou Tags: Research Articles Source Type: research