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Source: Cancer Research
Cancer: Clear Cell Carcinoma
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Total 1 results found since Jan 2013.
Abstract 4374: DCLK1 is a broadly dysregulated target against epithelial-mesenchymal transition, focal adhesion, and stemness in clear cell renal carcinoma
Renal clear cell carcinoma (RCC) is the most common type of kidney cancer and the 8th most common cancer overall in the US. RCC survival rates drop precipitously with regional and distant spread and recent studies have demonstrated that RCC presents an epithelial-mesenchymal transition (EMT) phenotype linked to increased recurrence and decreased survival. EMT is a key characteristic of tumor stem cells (TSCs) along with chemo-resistance and radio-resistance, which are also phenotypic of RCC.Targeting these factors is key to increasing the survival of RCC patients.Doublecortin-like kinase 1 (DCLK1) marks TSCs in pancreatic ...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Weygant, N., Qu, D., May, R., Tierney, R. M., Berry, W. L., Zhao, L., Agarwal, S., Chandrakesan, P., Sureban, S. M., Schlosser, M. J., Tomasek, J. J., Houchen, C. W. Tags: Experimental and Molecular Therapeutics Source Type: research
