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Source: Oncology Letters
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Total 421 results found since Jan 2013.
siRNA targeting RBP2 inhibits expression, proliferation, tumorigenicity and invasion in thyroid carcinoma cells.
In conclusion, the transfection of RBP2-siRNA into papillary thyroid carcinoma K1 cells suppressed the expression of RBP2 in these cells, and reduced their proliferation, invasion, migration and tumorigenic potential. Therefore, targeting RBP2 may be an efficient approach to control thyroid carcinoma.
PMID: 26788140 [PubMed - as supplied by publisher]
Source: Oncology Letters - January 21, 2016 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
Knockdown of β-catenin by siRNA influences proliferation, apoptosis and invasion of the colon cancer cell line SW480.
Authors: Li K, Zhou ZY, Ji PP, Luo HS
Abstract
The aim of the present study was to explore the effect of knocking down the expression of β-catenin by small interference (si)RNA on the activity of the Wnt/β-catenin signaling pathway, and the proliferation, apoptosis and invasion abilities of the human colon cancer cell line SW480. For that purpose, double-stranded siRNA targeting β-catenin (β-catenin-siRNA) was synthesized and transfected into SW480 cells. Reverse transcription-polymerase chain reaction (RT-PCR) and western blotting were used to detect the messenger (m)RNA and protein levels of β-catenin in SW4...
Source: Oncology Letters - June 19, 2016 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
Effect of combination therapy of siRNA targeting growth hormone receptor and 5-fluorouracil in hepatic metastasis of colon cancer.
Authors: Zhou D, Zhang YI, Liang D, Yuan Y, Zeng D, Chen J, Yang J
Abstract
The aim of this study was to investigate the effects of small interfering RNA (siRNA) targeting human growth hormone receptor (hGHR) combined with 5-fluorouracil (5-FU) on the hepatic metastasis of colon cancer. The animal model of liver metastases using human SW480 colon cancer cells was established on BALB/c mice and the siRNA interfering plasmid targeting hGHR gene was constructed. The tumor-bearing mice were randomly divided into the saline control, plasmid, growth hormone (GH), 5-FU, 5-FU+plasmid and 5-FU+plasmid+GH groups. The liver m...
Source: Oncology Letters - January 21, 2016 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
Effects of Grb2-associated binding protein 2-specific siRNA on the migration and invasion of MG-63 osteosarcoma cells.
Authors: Wang H, He H, Meng H, Cui Y, Wang W
Abstract
To investigate the association between the expression of growth factor receptor binding protein 2-associated binding protein 2 (Gab2) in human osteosarcoma as well as the effects of Gab2 on invasion and metastasis, human MG-63 osteosarcoma cells were transfected with small interfering (si)RNA plasmid. Gab2 protein and mRNA expression levels were detected using western blotting and reverse transcription-polymerase chain reaction, respectively. The cell migration and invasion abilities were detected using in vitro chemotaxis and invasion assays, respectively, foll...
Source: Oncology Letters - February 10, 2018 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
Construction of Ang2-siRNA chitosan magnetic nanoparticles and the effect on Ang2 gene expression in human malignant melanoma cells.
Authors: Liu ZL, You CL, Wang B, Lin JH, Hu XF, Shan XY, Wang MS, Zheng HB, Zhang YD
Abstract
The aim of the present study was to construct angiopoietin-2 (Ang2)-small interfering (si)RNA chitosan magnetic nanoparticles and to observe the interference effects of the nanoparticles on the expression of the Ang2 gene in human malignant melanoma cells. Ang2-siRNA chitosan magnetic nanoparticles were constructed and transfected into human malignant melanoma cells in vitro. Red fluorescent protein expression was observed, and the transfection efficiency was analyzed. Reverse transcription-quantitative polymerase chain re...
Source: Oncology Letters - June 19, 2016 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
siRNA-mediated knockdown of ID1 disrupts Nanog- and Oct-4-mediated cancer stem cell-likeness and resistance to chemotherapy in gastric cancer cells.
In conclusion, knockdown of ID1 attenuates the stem cell like-properties of self-renewal in normal GC cells, potentially through the targeting of Nanog and Oct-4, and subsequently decreases cell proliferation and resistance to DDP. The results of the present study suggest that ID1 functions as an oncogene in GC and regulates the stem cell like-properties of gastric cancer cells by targeting Nanog and Oct-4.
PMID: 28529558 [PubMed - in process]
Source: Oncology Letters - May 24, 2017 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
Antitumor activity of kinetochore-associated protein 2 siRNA against lung cancer patient-derived tumor xenografts.
Authors: Makita Y, Teratani M, Murata S, Hoashi Y, Matsumoto S, Kawamata Y
Abstract
It has been widely reported that patient-derived tumor xenografts (PDXs) are more similar to tumor tissues than conventional cancer cell lines. Kinetochore-associated protein 2 (KNTC2) is known to be upregulated specifically in tumor tissues of cancer patients and is recognized as a potential target for cancer therapy. Previously, in vivo antitumor activities of KNTC2 short interfering RNA encapsulated into a lipid nanoparticle (KNTC2-LNP) were reported in orthotopic hepatocellular carcinoma mouse models. However, it remains unclear...
Source: Oncology Letters - March 16, 2018 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
Intra-tumoral treatment with oxygen-ozone in glioblastoma: A systematic literature search and results of a case series.
Authors: Megele R, Riemenschneider MJ, Dodoo-Schittko F, Feyrer M, Kleindienst A
Abstract
Despite progress in surgery and radiochemotherapy, the prognosis of glioblastoma (GB) remains poor. GB cells exhibit a preference for hypoxia to maintain their tumor-forming capacity. Treatment strategies utilizing oxygen (O2) or ozone (O3) and generating reactive oxygen species induce cell growth inhibition and apoptosis. The anti-tumorigenic properties of O2-O3 are accompanied by a key role in regulating immunogenicity. The present study reported a case series of an intra-tumoral O2-O3 application in recurrent GB. Following ...
Source: Oncology Letters - October 23, 2018 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
"Oncol Lett"ta; +171 new citations
171 new pubmed citations were retrieved for your search.
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"Oncol Lett"[ta]
These pubmed results were generated on 2015/07/03PubMed comprises more than 24 million citations for biomedical literature from MEDLINE, life science journals, and online books.
Citations may include links to full-text content from PubMed Central and publisher web sites.
Source: Oncology Letters - July 3, 2015 Category: Cancer & Oncology Tags: Report Source Type: research
"Oncol Lett"ta; +102 new citations
102 new pubmed citations were retrieved for your search.
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"Oncol Lett"[ta]
These pubmed results were generated on 2015/07/15PubMed comprises more than 24 million citations for biomedical literature from MEDLINE, life science journals, and online books.
Citations may include links to full-text content from PubMed Central and publisher web sites.
Source: Oncology Letters - July 15, 2015 Category: Cancer & Oncology Tags: Report Source Type: research
"Oncol Lett"ta; +374 new citations
374 new pubmed citations were retrieved for your search.
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"Oncol Lett"[ta]
These pubmed results were generated on 2015/12/05PubMed comprises more than 24 million citations for biomedical literature from MEDLINE, life science journals, and online books.
Citations may include links to full-text content from PubMed Central and publisher web sites.
Source: Oncology Letters - December 5, 2015 Category: Cancer & Oncology Tags: Report Source Type: research
"Oncol Lett"ta; +110 new citations
110 new pubmed citations were retrieved for your search.
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"Oncol Lett"[ta]
These pubmed results were generated on 2016/01/12PubMed comprises more than 24 million citations for biomedical literature from MEDLINE, life science journals, and online books.
Citations may include links to full-text content from PubMed Central and publisher web sites.
Source: Oncology Letters - January 12, 2016 Category: Cancer & Oncology Tags: Report Source Type: research
"Oncol Lett"ta; +145 new citations
145 new pubmed citations were retrieved for your search.
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"Oncol Lett"[ta]
These pubmed results were generated on 2016/02/13PubMed comprises more than 24 million citations for biomedical literature from MEDLINE, life science journals, and online books.
Citations may include links to full-text content from PubMed Central and publisher web sites.
Source: Oncology Letters - February 13, 2016 Category: Cancer & Oncology Tags: Report Source Type: research
"Oncol Lett"ta; +122 new citations
122 new pubmed citations were retrieved for your search.
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"Oncol Lett"[ta]
These pubmed results were generated on 2016/02/20PubMed comprises more than 24 million citations for biomedical literature from MEDLINE, life science journals, and online books.
Citations may include links to full-text content from PubMed Central and publisher web sites.
Source: Oncology Letters - February 20, 2016 Category: Cancer & Oncology Tags: Report Source Type: research
"Oncol Lett"ta; +120 new citations
120 new pubmed citations were retrieved for your search.
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"Oncol Lett"[ta]
These pubmed results were generated on 2016/03/22PubMed comprises more than 24 million citations for biomedical literature from MEDLINE, life science journals, and online books.
Citations may include links to full-text content from PubMed Central and publisher web sites.
Source: Oncology Letters - March 23, 2016 Category: Cancer & Oncology Tags: Report Source Type: research
