Functional consequences of pathogenic variant c.61G>C in the inflammasome gene NLRP3 underlying keratitis fugax hereditaria
Conclusions
PBMCs from patients with KFH are more prone to secrete IL-1β, confirming the presumption that the c.61G>C is a gain-of-function variant. Furthermore, prednisolone is confirmed as a potent drug to reduce IL-1β secretion in KFH. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - January 29, 2024 Category: Opthalmology Authors: Kawan, S., Backlund, M. P., Immonen, A. T., Kivelä, T. T., Turunen, J. A. Tags: Original articles - Laboratory science Source Type: research
Fungal microbiome (mycobiome) and virome of the lacrimal sac in patients with PANDO: the lacriome paper 5
Conclusion
The present study is the first whole metagenome sequencing exclusively of the fungal microbiome and virome from the lacrimal sacs of patients with PANDO. The lacrimal sacs harbour diverse fungal and viral communities with distinct ecosystem dynamics. Further studies of their functions and interactions with the hosts would provide valuable insights. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - January 29, 2024 Category: Opthalmology Authors: Ali, M. J. Tags: Original articles - Laboratory science Source Type: research
Associations of vision impairment and eye diseases with frailty in community-dwelling older adults: a nationwide longitudinal study in China
Conclusions
Vision problem, vision impairment and glaucoma are important predictors of frailty in older adults. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - January 29, 2024 Category: Opthalmology Authors: Shang, X., Wu, G., Wang, W., Zhu, Z., Zhang, X., Huang, Y., Hu, Y., He, M., Yu, H. Tags: Epidemiology Source Type: research
Persistence of severe global inequalities in the burden of blindness and vision loss from 1990 to 2019: findings from the Global Burden of Disease Study 2019
Conclusion
Though countries with middle and low-middle SDI were the most successful in decreasing burden of blindness and vision loss, a high level of cross-national health inequality persisted over the past three decades. More attention must be paid to the elimination of avoidable blindness and vision loss in low-income and middle-income countries. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - January 29, 2024 Category: Opthalmology Authors: Li, Y., Wang, H., Guan, Z., Guo, C., Guo, P., Du, Y., Yin, S., Chen, B., Jiang, J., Ma, Y., Jing, L., Huang, Y., Zheng, K., Ma, Q., Zhou, R., Chen, M., Congdon, N., Qiu, K., Zhang, M. Tags: Epidemiology Source Type: research
Presentation of Graves orbitopathy within European Group On Graves Orbitopathy (EUGOGO) centres from 2012 to 2019 (PREGO III)
Conclusion
GO patients are referred to tertiary EUGOGO centres in a less severe stage of the disease than before. We speculate that this might be linked to a broader awareness of the disease and faster and adequate delivered treatment. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - January 29, 2024 Category: Opthalmology Authors: Schuh, A., Ayvaz, G., Baldeschi, L., Baretic, M., Bechtold, D., Boschi, A., Brix, T. H., Burlacu, M.-C., Ciric, J., Covelli, D., Curro, N., Donati, S., Eckstein, A. K., Fichter, N., Führer, D., Horn, M., Jabłonska-Pawlak, A., Juri Mandic, J Tags: Open access Oculoplastic and orbit Source Type: research
An interpretable model predicts visual outcomes of no light perception eyes after open globe injury
Conclusions
VisionGo has achieved an accurate and reliable prediction in visual outcome after vitrectomy for OGI-NLP eyes. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - January 29, 2024 Category: Opthalmology Authors: Meng, X., Wang, Q., Chen, S., Zhang, S., Yu, J., Li, H., Chen, X., Wang, Z., Yu, W., Zheng, Z., Zhou, H., Luo, J., Wang, Z., Chen, H., Wu, N., Hu, D., Chen, S., Wei, Y., Cui, H., Song, H., Chen, H., Wang, Y., Zhong, J., Chen, Z., Zhang, H., Yang, T., Li, Tags: Ocular trauma Source Type: research
Distribution and causes of blindness and severe visual impairment in children at a tertiary referral centre in Rwanda
Conclusion
The high number of avoidable causes for SVI/BL may be reduced through several cost-effective ways. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - January 29, 2024 Category: Opthalmology Authors: El-Khoury, S., Strittmatter, S., Tuyisabe, T., Preussner, P.-R., Abdelmassih, Y. Tags: Paediatric ophthalmology Source Type: research
Quantitative analysis of choriocapillaris flow deficits and choroidal thickness in children with Marfan syndrome
Conclusions
Thinner ChT and a higher CC FD% were observed in children with MFS, and an increased CC FD% in circle 2.5 mm was significantly associated with worse BCVA and cardiac function. These findings may help identify future visual impairment and early cardiac events in MFS children. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - January 29, 2024 Category: Opthalmology Authors: Ng, K., Xu, P., Jin, G., Cheng, W., Luo, X., Ding, X., Zheng, D., Liu, Y. Tags: Paediatric ophthalmology Source Type: research
Validation of a deep learning system for the detection of diabetic retinopathy in Indigenous Australians
Conclusion
The DLS showed improved sensitivity and similar specificity compared with a retina specialist for DR detection. This demonstrates its potential to support DR screening among Indigenous Australians, an underserved population with a high burden of diabetic eye disease. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - January 29, 2024 Category: Opthalmology Authors: Chia, M. A., Hersch, F., Sayres, R., Bavishi, P., Tiwari, R., Keane, P. A., Turner, A. W. Tags: Open access Retina Source Type: research
Hyperpigmentary abnormalities in age-related macular degeneration: association with progression and impact on visual sensitivity
Conclusion
In a cohort with bilateral large drusen, quantifying HPA extent did not improve the prediction of late AMD development compared with presence alone. HPA extent was associated with more local, rather than generalised, reductions in visual sensitivity. These findings suggest that quantification of HPA extent adds little to the prediction of AMD progression, but that it provides an imaging biomarker of visual dysfunction. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - January 29, 2024 Category: Opthalmology Authors: Goh, K. L., Kumar, H., Hadoux, X., Jannaud, M., Abbott, C., Hodgson, L., Robman, L., Makeyeva, G., Van Wijngaarden, P., Guymer, R., Wu, Z. Tags: Retina Source Type: research
Artificial intelligence-based fluid quantification and associated visual outcomes in a real-world, multicentre neovascular age-related macular degeneration national database
Conclusion
This real-world study describes an AI-based analysis of fluid dynamics and defines baseline OCT-based patient profiles that associate 12-month visual outcomes in a large cohort of treated naïve nAMD eyes nationwide. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - January 29, 2024 Category: Opthalmology Authors: Martin-Pinardel, R., Izquierdo-Serra, J., De Zanet, S., Parrado-Carrillo, A., Garay-Aramburu, G., Puzo, M., Arruabarrena, C., Sararols, L., Abraldes, M., Broc, L., Escobar-Barranco, J. J., Figueroa, M., Zapata, M. A., Ruiz-Moreno, J. M., Moll-Udina, A., B Tags: Retina Source Type: research
Efficacy and safety of abatacept to treat active birdshot uveitis: a prospective open label interventional proof-of-concept trial
Conclusions
Abatacept is very efficacious to treat both retinal vasculitis and choroiditis in patients with BU and is well tolerated. BCVA and CRT are inadequate to monitor disease activity. On the other hand, CCT is a promising non-invasive tool to detect treatment response in early active BU and dual FA-ICGA Score is very helpful to evaluate retinal vasculitis and choroiditis quantitatively.
Trial registration number
NCT03871361. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - January 29, 2024 Category: Opthalmology Authors: Schauwvlieghe, P., Van Calster, J., Herbort, C. P., Kestelyn, P. A., de Vlam, K. Tags: Open access Intraocular infection and inflammation Source Type: research
Safety and effectiveness of intravitreal dexamethasone implant in patients with ocular toxocariasis
Conclusions
This was the first study to investigate use of intravitreal DEX implant in OT patients, which can efficiently reduce ocular inflammation and improve BCVA in macular uninvolved patients. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - January 29, 2024 Category: Opthalmology Authors: Sun, L., Huang, L., Li, S., Lu, J., Zheng, S., Ding, X. Tags: Intraocular infection and inflammation Source Type: research
Endophthalmitis rates and risk factors following intraocular surgeries in the medicare population from 2016 to 2019
Conclusions
Postoperative endophthalmitis rate after intraocular surgeries was 0.09% between 2016 and 2019 for Medicare beneficiaries. Endophthalmitis rates were highest for corneal transplant surgeries followed by secondary IOL surgeries and lowest for cataract surgeries. Older age, male gender and higher comorbidity index were associated with risk of endophthalmitis. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - January 29, 2024 Category: Opthalmology Authors: Chen, A., Dun, C., Schein, O. D., Srikumaran, D., Zafar, S., Makary, M., Woreta, F. Tags: Editor's choice Intraocular infection and inflammation Source Type: research
AI-based clinical assessment of optic nerve head robustness superseding biomechanical testing
Conclusions
We propose an AI-driven approach that can assess the robustness of a given ONH solely from a single OCT volume scan of the ONH, and without the need to perform biomechanical testing. Longitudinal studies should establish whether ONH robustness could help us identify fast visual field loss progressors.
Precis
Using geometric deep learning, we can assess optic nerve head robustness (ie, sensitivity to a change in IOP) from a standard OCT scan that might help to identify fast visual field loss progressors. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - January 29, 2024 Category: Opthalmology Authors: Braeu, F. A., Chuangsuwanich, T., Tun, T. A., Perera, S., Husain, R., Thiery, A. H., Aung, T., Barbastathis, G., Girard, M. J. A. Tags: Glaucoma Source Type: research
