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Cholesterol accumulation on dendritic cells reverses chronic hepatitis B virus infection-induced dysfunction
Cell Mol Immunol. 2022 Nov 11. doi: 10.1038/s41423-022-00939-1. Online ahead of print.ABSTRACTChronic hepatitis B (CHB) infection remains a serious public health problem worldwide; however, the relationship between cholesterol levels and CHB remains unclear. We isolated peripheral blood mononuclear cells from healthy blood donors and CHB patients to analyze free cholesterol levels, lipid raft formation, and cholesterol metabolism-related pathways. Hepatitis B virus (HBV)-carrier mice were generated and used to confirm changes in cholesterol metabolism and cell-surface lipid raft formation in dendritic cells (DCs) in the co...
Source: Cellular and Molecular Immunology - November 12, 2022 Category: Molecular Biology Authors: Huajun Zhao Yating Yu Yucan Wang Lianhui Zhao Ailu Yang Yifei Hu Zhaoyi Pan Zixuan Wang Jiarui Yang Qiuju Han Zhigang Tian Jian Zhang Source Type: research

With vaccines…Is there no middle ground, no room for questions?
“We should be as demanding of ourselves as we are of those who challenge us.” Dr. Jerome Groopman, writing in the New Rupublic Writing about the medical decision-making surrounding vaccines proved to be sketchy. Yesterday’s post brought stinging criticism from both sides of the debate. A pediatrician felt the structure of the post was patronizing. Just an hour later, a skeptic sent me the same message–patronizing. This was educational. Criticism is taken seriously here, especially when it comes from both sides of an argument. The reflex: Perhaps its useful to write more on the matter? (It’s f...
Source: Dr John M - December 6, 2013 Category: Cardiology Authors: Dr John Source Type: blogs