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Specialty: Biomedical Science
Vaccination: Veterinary Vaccinations
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Total 238 results found since Jan 2013.
Broadening a SARS-CoV-1-neutralizing antibody for potent SARS-CoV-2 neutralization through directed evolution
Sci Signal. 2023 Aug 15;16(798):eabk3516. doi: 10.1126/scisignal.abk3516. Epub 2023 Aug 15.ABSTRACTThe emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) underscores the need for strategies to rapidly develop neutralizing monoclonal antibodies that can function as prophylactic and therapeutic agents and to help guide vaccine design. Here, we demonstrate that engineering approaches can be used to refocus an existing antibody that neutralizes one virus but not a related virus. Through a rapid affinity maturation strategy, we engineered CR3022, a SARS-CoV-1-neutralizing antibody, to bind to the receptor...
Source: Science Signaling - August 15, 2023 Category: Biomedical Science Authors: Fangzhu Zhao Meng Yuan Celina Keating Namir Shaabani Oliver Limbo Collin Joyce Jordan Woehl Shawn Barman Alison Burns Quoc Tran Xueyong Zhu Michael Ricciardi Linghang Peng Jessica Smith Deli Huang Bryan Briney Devin Sok David Nemazee John R Teijaro Ian A Source Type: research
Vaccination with celecoxib-treated dendritic cells improved cellular immune responses in an animal breast cancer model
CONCLUSIONS: Our findings show that LPS/CXB-treated DC vaccine potently modulated antitumor immune responses in a mouse BC model.PMID:37003235 | DOI:10.1016/j.advms.2023.03.002
Source: Advances in Medical Sciences - April 1, 2023 Category: Biomedical Science Authors: Raziyeh Zandvakili Pedram Basirjafar Javad Masoumi Nahid Zainodini Zahra Taghipour Hossein Khorramdelazad Soheila Yousefi Tayyebeh Tavakoli Sepehr Safdel Mahsa Gheitasi Fatemeh Ayoobi Abdollah Jafarzadeh Source Type: research
