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Total 30301 results found since Jan 2013.

Vitamin D Supplementation and the Risk of Colds in Patients with Asthma.
CONCLUSION: In patients with mild-to-moderate asthma undergoing an ICS dose-reduction, these results do not support the use of vitamin D supplementation for the purpose of reducing cold severity or frequency. Clinical trial registration available at www.clinicaltrials.gov, ID NCT01248065. PMID: 26540136 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - November 5, 2015 Category: Respiratory Medicine Authors: Denlinger LC, King TS, Cardet JC, Craig T, Holguin F, Jackson DJ, Kraft M, Peters SP, Ross K, Sumino K, Boushey HA, Jarjour NN, Wechsler ME, Wenzel SE, Castro M, Avila PC, National Heart Lung and Blood Institute AsthmaNet Investigators Tags: Am J Respir Crit Care Med Source Type: research

Lung Deflation and Cardiovascular Structure and Function in COPD: A Randomized Controlled Trial.
CONCLUSIONS: Pharmacological treatment of chronic obstructive pulmonary disease has consistent beneficial and plausible effects on cardiac function and pulmonary vasculature that may contribute to favorable effects of inhaled therapies. Future studies should investigate the effect of prolonged lung deflation on intrinsic myocardial function. Clinical trial registration available at www.clinicaltrials.gov, ID NCT01691885. PMID: 26550687 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - November 9, 2015 Category: Respiratory Medicine Authors: Stone IS, Barnes NC, James WY, Midwinter D, Boubertakh R, Follows R, John L, Petersen SE Tags: Am J Respir Crit Care Med Source Type: research

Blood Eosinophils and Exacerbations in COPD: the Copenhagen General Population Study.
CONCLUSIONS: Among individuals with COPD in the general population, increased blood eosinophil levels above 0.34∙10(9) cells/L were associated with a 1.76-fold increased risk of severe exacerbations. PMID: 26641631 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - December 7, 2015 Category: Respiratory Medicine Authors: Vedel-Krogh S, Nielsen SF, Lange P, Vestbo J, Nordestgaard BG Tags: Am J Respir Crit Care Med Source Type: research

Accuracy and Reliability of Internet Resources for Information on Idiopathic Pulmonary Fibrosis.
CONCLUSIONS: Patient-directed online information on IPF is frequently incomplete, inaccurate, and outdated. There is no reliable method for patients to identify sites that provide appropriate information on IPF. PMID: 26849779 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - February 5, 2016 Category: Respiratory Medicine Authors: Fisher JH, O'Connor D, Flexman AM, Shapera S, Ryerson CJ Tags: Am J Respir Crit Care Med Source Type: research

Steroid-induced Deficiency of Mucosal-associated Invariant T Cells in the COPD Lung: Implications for NTHi Infection.
CONCLUSIONS: MAIT cells are deficient in blood and bronchial tissue in steroid-treated, but not steroid-naïve COPD. NTHi constitutes a target for pulmonary MAIT cell immune responses, which are significantly impaired by corticosteroids. PMID: 27115408 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - April 25, 2016 Category: Respiratory Medicine Authors: Hinks TS, Wallington JC, Williams AP, Djukanović R, Staples KJ, Wilkinson TM Tags: Am J Respir Crit Care Med Source Type: research

Inflammatory and Co-Morbid Features of Patients with Severe Asthma and Frequent Exacerbations.
CONCLUSIONS: EPA may be a distinct susceptibility phenotype with implications for the targeting of exacerbation prevention strategies. Clinical trial registration available at www.clinicaltrials.gov, ID NCT01760915. PMID: 27556234 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - August 23, 2016 Category: Respiratory Medicine Authors: Denlinger LC, Phillips BR, Ramratnam S, Ross K, Bhakta NR, Cardet JC, Castro M, Peters SP, Phipatanakul W, Aujla S, Bacharier LB, Bleecker ER, Comhair SA, Coverstone A, DeBoer M, Erzurum SC, Fain SB, Fajt M, Fitzpatrick AM, Gaffin J, Gaston B, Hastie AT, Tags: Am J Respir Crit Care Med Source Type: research

A Transcriptome-driven Analysis of Epithelial Brushings and Bronchial Biopsies to Define Asthma Phenotypes in U-BIOPRED.
CONCLUSION: This analysis demonstrates the usefulness of a transcriptomic-driven approach to phenotyping that segments patients who may benefit the most from specific agents that target Th2-mediated inflammation and/or corticosteroid insensitivity. PMID: 27580351 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - August 30, 2016 Category: Respiratory Medicine Authors: Kuo CS, Pavlidis S, Loza M, Baribaud F, Rowe A, Pandis I, Hoda U, Rossios C, Sousa A, Wilson SJ, Howarth P, Dahlen B, Dahlen SE, Chanez P, Shaw D, Krug N, Sandström T, De Meulder B, Lefaudeux D, Fowler S, Fleming L, Corfield J, Auffray C, Sterk PJ, Djuka Tags: Am J Respir Crit Care Med Source Type: research

Biomarkers Predictive of Exacerbations in the SPIROMICS and COPDGene Cohorts.
CONCLUSION: Blood biomarkers were significantly associated with the occurrence of exacerbations but were not robust between cohorts and added little to the predictive value of clinical covariates for exacerbations. PMID: 27579823 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - August 30, 2016 Category: Respiratory Medicine Authors: Keene JD, Jacobson S, Kechris K, Kinney GL, Foreman MG, Doerschuk CM, Make BJ, Curtis JL, Rennard SI, Barr RG, Bleecker ER, Kanner RE, Kleerup EC, Hansel NN, Woodruff PG, Han MK, Paine Iii R, Martinez FJ, Bowler RP, O'Neal WK, for COPDGene and SPIROMICS I Tags: Am J Respir Crit Care Med Source Type: research

Effect of Roflumilast and Inhaled Corticosteroid/Long-Acting β2-Agonist on Chronic Obstructive Pulmonary Disease Exacerbations (RE(2)SPOND). A Randomized Clinical Trial.
CONCLUSIONS: Roflumilast failed to statistically significantly reduce moderate and/or severe exacerbations in the overall population. Roflumilast improved lung function and reduced exacerbations in participants with frequent exacerbations and/or hospitalization history. The safety profile of roflumilast was consistent with that of previous studies. Clinical trial registered with www.clinicaltrials.gov (NCT01443845). PMID: 27585384 [PubMed - in process]
Source: American Journal of Respiratory and Critical Care Medicine - August 31, 2016 Category: Respiratory Medicine Authors: Martinez FJ, Rabe KF, Sethi S, Pizzichini E, McIvor A, Anzueto A, Alagappan VK, Siddiqui S, Rekeda L, Miller CJ, Zetterstrand S, Reisner C, Rennard SI Tags: Am J Respir Crit Care Med Source Type: research

Preeclampsia Associates with Asthma, Allergy and Eczema in Childhood.
Conclusions Preeclampsia is a shared prenatal risk factor for asthma, eczema and allergy in childhood pointing towards in-utero immune programming of the child. PMID: 27626972 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - September 13, 2016 Category: Respiratory Medicine Authors: Stokholm J, Sevelsted A, Anderson UD, Bisgaard H Tags: Am J Respir Crit Care Med Source Type: research

Fluctuation Analysis of Peak Expiratory Flow and its Association with Treatment Failure in Asthma.
CONCLUSIONS: We conclude that increased temporal self-similarity (α) of more variable lung function (CVPEF) is associated with treatment failure, but the pattern of change in self-similarity leading up to treatment failure is variable across individuals. PMID: 27814453 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - November 3, 2016 Category: Respiratory Medicine Authors: Kaminsky DA, Wang LL, Bates JH, Thamrin C, Shade DM, Dixon AE, Wise RA, Peters S, Irvin CG Tags: Am J Respir Crit Care Med Source Type: research

Inhaled Corticosteroids in Chronic Obstructive Pulmonary Disease. A Two-Edged Sword.
PMID: 27845580 [PubMed - in process]
Source: American Journal of Respiratory and Critical Care Medicine - November 14, 2016 Category: Respiratory Medicine Authors: Riesbeck K Tags: Am J Respir Crit Care Med Source Type: research

How Do Dual Long-acting Bronchodilators Prevent Exacerbations of Chronic Obstructive Pulmonary Disease?
Abstract Decreasing the frequency and severity of exacerbations is one of the main goals of treatment for patients with chronic obstructive pulmonary disease (COPD). Several studies have documented that long-acting bronchodilators (LABDs) can reduce exacerbation rate and/or severity, and others have shown that combinations of long-acting 2-adrenergic agonists (LABAs) and long-acting muscarinic antagonists (LAMAs) provide greater reductions in exacerbation frequency than either their monocomponents or LABA/inhaled corticosteroids (LABA/ICS) combinations in patients at low and high risk for these events. In this ...
Source: American Journal of Respiratory and Critical Care Medicine - December 5, 2016 Category: Respiratory Medicine Authors: Beeh KM, Burgel PR, Franssen FM, Lopez-Campos JL, Loukides S, Hurst JR, Fležar M, Ulrik CS, Di Marco F, Stolz D, Valipour A, Casserly B, Ställberg B, Kostikas K, Wedzicha JA Tags: Am J Respir Crit Care Med Source Type: research

Gene Expression Correlated to Severe Asthma Characteristics Reveals Heterogeneous Mechanisms of Severe Disease.
CONCLUSIONS: In this hypothesis-generating analysis, gene expression networks in relation to asthma severity provides potentially new insight into biological mechanisms associated with the development of SA and its phenotypes. PMID: 27984699 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - December 15, 2016 Category: Respiratory Medicine Authors: Modena BD, Bleecker ER, Busse WW, Erzurum SC, Gaston BM, Jarjour NN, Meyers DA, Milosevic J, Tedrow JR, Wu W, Kaminski N, Wenzel SE Tags: Am J Respir Crit Care Med Source Type: research

Blood Eosinophils and Response to Maintenance COPD Treatment: Data from the FLAME Trial.
CONCLUSIONS: Our prospective analyses indicate that indacaterol/glycopyrronium provides superior or similar benefits over salmeterol/fluticasone regardless of blood eosinophil levels in patients with COPD. Clinical trial registration available at www.clinicaltrials.gov, ID NCT01782326. PMID: 28278391 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - March 8, 2017 Category: Respiratory Medicine Authors: Roche N, Chapman KR, Vogelmeier CF, Herth FJ, Thach C, Fogel R, Olsson P, Patalano F, Banerji D, Wedzicha JA Tags: Am J Respir Crit Care Med Source Type: research