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Specialty: Cancer & Oncology
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Total 124121 results found since Jan 2013.
Rapid Detection of bla < sub > KPC < /sub > in Carbapenem-Resistant Enterobacterales Based on CRISPR/Cas13a
In conclusion, the RPA-Cas13a system is a simple and one-hour efficient technology for the detection of a potentially fatal antibiotic resistance gene.PMID:37737960 | DOI:10.1007/s00284-023-03457-z
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Mingjun Liang Bin Xiao Lidan Chen Xiaoyan Huang Jinchao Li Zhenzhan Kuang Xinping Chen Xiuna Huang Zhaohui Sun Linhai Li Source Type: research
Peroxisomal ROS control cytosolic Mycobacterium tuberculosis replication in human macrophages
J Cell Biol. 2023 Dec 4;222(12):e202303066. doi: 10.1083/jcb.202303066. Epub 2023 Sep 22.ABSTRACTPeroxisomes are organelles involved in many metabolic processes including lipid metabolism, reactive oxygen species (ROS) turnover, and antimicrobial immune responses. However, the cellular mechanisms by which peroxisomes contribute to bacterial elimination in macrophages remain elusive. Here, we investigated peroxisome function in iPSC-derived human macrophages (iPSDM) during infection with Mycobacterium tuberculosis (Mtb). We discovered that Mtb-triggered peroxisome biogenesis requires the ESX-1 type 7 secretion system, criti...
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Enrica Pellegrino Beren Aylan Claudio Bussi Antony Fearns Elliott M Bernard Natalia Athanasiadi Pierre Santucci Laure Botella Maximiliano G Gutierrez Source Type: research
The impact of intensified staging and combined therapies in locally advanced pancreatic cancer: a secondary analysis of prospective studies
CONCLUSIONS: The use of comprehensive pre-treatment staging, including laparoscopy and 18F-FDG-PET/CT scan, is an effective approach in identifying occult metastatic disease in LAPC patients. Our findings offer valuable insights into accurate staging and treatment efficacy, providing evidence-based support for optimal management strategies in LAPC patients.PMID:37737898 | DOI:10.1097/JS9.0000000000000755
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Michele Fiore Gian Marco Petrianni Pasquale Trecca Gabriele D'Ercole Alessandro Coppola Vincenzo La Vaccara Silvia Taralli Paola Cimini Carlo Greco Edy Ippolito Maria Lucia Calcagni Bruno Beomonte Zobel Damiano Caputo Roberto Coppola Sara Ramella Rolando Source Type: research
Harnessing Dendritic Cells: Next Frontier for Durable Immune Control in Myeloma
Clin Cancer Res. 2023 Sep 22:OF1-OF3. doi: 10.1158/1078-0432.CCR-23-2292. Online ahead of print.ABSTRACTImmune-based approaches including T-cell redirection have transformed the therapeutic landscape in myeloma. Injection of dendritic cells (DC) led to the induction of immune responses in vaccinated patients with myeloma. These studies pave the way for future combination strategies harnessing DCs to enhance tumor immunity and improve outcomes in myeloma. See related article by Freeman et al., p. 000.PMID:37737650 | DOI:10.1158/1078-0432.CCR-23-2292
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Madhav V Dhodapkar Source Type: research
Prevalence and predictors of colorectal cancer screening in the United States: evidence from the HINTS database 2018 to 2020
CONCLUSION: CRC screening rates among adults 45-49 years are low but are increasing steadily. Odds of CRC screening among Blacks is high which is encouraging while the odds among current smokers is low and concerning given their increased risk of developing CRC.PMID:37737304 | DOI:10.1007/s10552-023-01795-8
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Joseph Atarere Christopher Haas Ted Akhiwu Thilini Delungahawatta Ashik Pokharel Comfort Adewunmi Eugene Annor Vwaire Orhurhu Jasmine Barrow Source Type: research
Untargeted serum metabolomic profiles and breast density in young women
CONCLUSION: Our results suggest an inverse association of branched chain amino acids with %DBV. Larger studies in diverse populations are needed.PMID:37737303 | DOI:10.1007/s10552-023-01793-w
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Seungyoun Jung Sarah Silva Cher M Dallal Erin LeBlanc Kenneth Paris John Shepherd Linda G Snetselaar Linda Van Horn Yuji Zhang Joanne F Dorgan Source Type: research
Association between weight loss agents and elevated liver enzymes: a population-based cross-sectional study
This study aimed to investigate the associations between weight loss agents and elevated liver enzymes at the population-level. We conducted a cross-sectional study using Korea National Health and Nutrition Examination Survey (KNHANES) data from 2013 to 2019. This study included 36,259 participants over 20 years of age who completed the questionnaire and had no history of hepatitis, cancer, or renal failure. In these participants, we analyzed associations between weight loss agents and elevated liver enzymes by constructing multiple logistic regression models with adjustment for confounding factors and stratified by sex, a...
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Ye-Jee Kim Seo Young Kang Mi-Sook Kim Joongyub Lee Bo Ram Yang Source Type: research
Regional disparities in suicide among patients with cancer: A nationwide population-based study in Japan
CONCLUSION: The results demonstrated that patients with cancer in certain prefectures in Japan have a high suicide risk.PMID:37737044 | DOI:10.1002/cam4.6574
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Ken Kurisu Saki Harashima Maiko Fujimori Tatsuo Akechi Kazuhiro Yoshiuchi Yosuke Uchitomi Source Type: research
Fetal Exposure to Preeclampsia and Later Risk of Cardiometabolic Disorders: A Population-Based Cohort Study
CONCLUSIONS: Fetal preeclampsia exposure was associated with adult life hypertension, diabetes, and dyslipidemia, but these associations were likely due to shared etiological factors, rather than exposure to the preeclamptic condition itself.PMID:37737002 | DOI:10.1161/HYPERTENSIONAHA.122.20682
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Abira Paramsothy Tor-Arne Hegvik Anders Engeland Tone Bj ørge Grace M Egeland Kari Klungs øyr Source Type: research
Health equity in action: using community-engaged research to update an intervention promoting a healthy home food environment to Black/African American families
CONCLUSION: The Delphi Technique shows promise as a method for conducting community-engaged research that promotes engagement and identifies key information needed to adapt and implement an existing intervention in a community setting.PMID:37736870 | DOI:10.1007/s10552-023-01753-4
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Debbe Thompson Chishinga Callender Jayna M Dave Maria L Jibaja-Weiss Jane R Montealegre Source Type: research
Oncolytic virus oHSV2 combined with PD-1/PD-L1 inhibitors exert antitumor activity by mediating CD4 + T and CD8 + T cell infiltration in the lymphoma tumor microenvironment
Autoimmunity. 2023 Dec;56(1):2259126. doi: 10.1080/08916934.2023.2259126. Epub 2023 Sep 22.ABSTRACTA novel therapeutic regimen showed that the oncolytic type II herpes simplex virus (oHSV2) was able to prevent colorectal cancer growth, recurrence, and metastasis. However, no study has yet explored whether oHSV2 has an impact on the development of diffuse large B-cell lymphoma (DLBCL). We chose the clinical chemotherapeutic drug doxorubicin (DOX) as a positive control to evaluate the effect of oHSV2 infection on the apoptotic, invasive, and proliferative capacity of DLBCL cells. We next further explored the therapeutic effi...
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Jingbo Zhang Yiwei Guo Huiying Fang Xiuchen Guo Lina Zhao Source Type: research
Correction to: A comparison of two techniques of postoperative analgesia: lignocaine-fentanyl intravenous infusion and ropivacaine-fentanyl epidural infusion in patients undergoing cytoreductive cancer surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC)-prospective randomized control study
Langenbecks Arch Surg. 2023 Sep 22;408(1):370. doi: 10.1007/s00423-023-03113-x.NO ABSTRACTPMID:37736776 | DOI:10.1007/s00423-023-03113-x
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Kiran Mahendru Rakesh Garg Sachidanand Jee Bharati Vinod Kumar Nishkarsh Gupta Seema Mishra Sushma Bhatnagar Mukurdipi Ray Suryanarayana Deo Source Type: research
Outcome of cancer patients after atrial fibrillation ablation: Insights from the China-AF registry
CONCLUSIONS: This study suggests that catheter ablation could be feasible for rhythm control of AF patients with concomitant cancer.PMID:37736690 | DOI:10.1111/pace.14830
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Xiaodong Peng Liu He Nian Liu Yanfei Ruan Xin Zhao Xueyuan Guo Wei Wang Songnan Li Ribo Tang Caihua Sang Chenxi Jiang Ronghui Yu Deyong Long Xin Du Jianzeng Dong Changsheng Ma Source Type: research
Argon-helium knife cryoablation plus programmed cell death protein 1 inhibitor in the treatment of advanced soft tissue sarcomas: there is no evidence of the synergistic effects of this combination therapy
CONCLUSION: Cryoablation combined with PD-1 inhibitors in the therapy of advanced STS is safe and can effectively shrink the cryoablation-target lesion. However, there is no evidence of the synergistic effects of this combination therapy.PMID:37736543 | PMC:PMC10509548 | DOI:10.3389/fonc.2023.1185291
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Jiaqiang Wang Dengwei Zong Shuping Dong Shilei Gao Yonghao Yang Peng Zhang Xin Wang Weitao Yao Zhichao Tian Source Type: research
Automated radiosynthesis of < sup > 18 < /sup > FFMPEP- < em > d < /em > < sub > 2 < /sub > for cannabinoid receptor PET imaging
Am J Nucl Med Mol Imaging. 2023 Aug 15;13(4):171-178. eCollection 2023.ABSTRACTThe cannabinoid subtype 1 receptor (CB1R) is highly expressed in the central nervous system and abnormalities in regional CB1R density are associated with neurodegenerative disorders. The PET tracer [18F]FMPEP-d2 is an inverse CB1R agonist which was shown to be suitable for non-invasive PET imaging. In this work, we reported the fully automated radiosynthesis of [18F]FMPEP-d2 on a Synthra RNplus research module. In a total synthesis time of 70 min, [18F]FMPEP-d2 was obtained in 2.2 ± 0.1 GBq (n = 3) with excellent radiochemical and chemical pur...
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Huailei Jiang Yan Guo Otto Muzik Source Type: research
