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Total 141452 results found since Jan 2013.

SCCM Pod-463 CCM: Clazakizumab for COVID-19: Friend or Foe?
Clazakizumab is a monoclonal antibody against human interleukin-6 that may benefit patients hospitalized with severe or critical COVID-19 accompanied by hyperinflammation. Although not yet FDA approved, clinical trials of clazakizumab for treatment of COVID-19 are under way worldwide. Samantha Gambles Farr, MSN, NP-C, CCRN, RNFA, is joined by Bonnie E. Lonze, MD, PhD, to discuss the article, A Randomized Double-Blinded Placebo Controlled Trial of Clazakizumab for the Treatment of COVID-19 Pneumonia With Hyperinflammation, published in the September 2022 issue of Critical Care Medicine. Dr. Lonze is a faculty transplant sur...
Source: SCCM PodCast - iCritical Care - December 21, 2022 Category: Intensive Care Authors: The Society of Critical Care Medicine (SCCM) Tags: Medicine Source Type: podcasts

Candidacy for Extracorporeal Life Support in Children After Hematopoietic Cell Transplantation: A Position Paper From the Pediatric Acute Lung Injury and Sepsis Investigators Network’s Hematopoietic Cell Transplant and Cancer Immunotherapy Subgroup
CONCLUSIONS: Extracorporeal life support in hematopoietic cell transplantation patients is being used with increasing frequency and potentially improving survival. The Pediatric Acute Lung Injury and Sepsis Investigators hematopoietic cell transplantation-cancer immunotherapy subgroup has developed a framework to guide physicians in decision-making surrounding extracorporeal life support candidacy in pediatric hematopoietic cell transplantation patients. In addition to standard extracorporeal life support considerations, candidacy in the hematopoietic cell transplantation population should consider the following six fa...
Source: Pediatric Critical Care Medicine - March 1, 2022 Category: Pediatrics Tags: Special Article Source Type: research

Racial and Ethnic Differences in Inpatient Palliative Care for Pediatric Stem Cell Transplant Patients*
CONCLUSIONS: Racial and ethnic differences exist in the likelihood of receiving palliative care consultations among hospitalized pediatric stem cell transplant recipients. Evaluating the impact of systemic racism and social determinants on palliative care medicine as well as standardizing early integration of IPCC may potentially mitigate disparities in this population.
Source: Pediatric Critical Care Medicine - June 1, 2022 Category: Pediatrics Tags: Feature Articles Source Type: research

Invasive Mechanical Ventilation and Mortality in Pediatric Hematopoietic Stem Cell Transplantation: A Multicenter Study*
Conclusions: This study suggests that perhaps earlier more aggressive critical care interventions in the pediatric hematopoietic stem cell transplant patient with respiratory failure requiring invasive mechanical ventilation may offer an opportunity to improve outcomes.
Source: Pediatric Critical Care Medicine - April 1, 2016 Category: Pediatrics Tags: Feature Articles Source Type: research

The Use of Pediatric Ventricular Assist Devices in Children’s Hospitals From 2000 to 2010: Morbidity, Mortality, and Hospital Charges*
Objective: The use of ventricular assist devices has increased dramatically in adult heart failure patients. However, the overall use, outcome, comorbidities, and resource utilization of ventricular assist devices in pediatric patients have not been well described. We sought to demonstrate that the use of ventricular assist devices in pediatric patients has increased over time and that mortality has decreased. Design: A retrospective study of the Pediatric Health Information System database was performed for patients 20 years old or younger undergoing ventricular assist device placement from 2000 to 2010. Interventions: No...
Source: Pediatric Critical Care Medicine - July 1, 2015 Category: Pediatrics Tags: Cardiac Intensive Care Source Type: research

Acute Kidney Injury in Pediatric Acute Decompensated Heart Failure
Objective: Acute kidney injury in adult patients with acute decompensated heart failure is associated with increased mortality. There is limited literature in pediatric patients with acute decompensated heart failure and acute kidney injury. We aim to study acute kidney injury in the pediatric acute decompensated heart failure population and its association with specific outcomes. Design: Retrospective, case-control study. Setting: Cardiac ICU in a children’s tertiary care hospital. Patients: Index admissions of patients younger than 21 years with acute decompensated heart failure between January 2008 and December 2012. ...
Source: Pediatric Critical Care Medicine - July 1, 2015 Category: Pediatrics Tags: Cardiac Intensive Care Source Type: research

Children in Critical Care Due to Severe Acute Respiratory Syndrome Coronavirus 2 Infection: Experience in a Spanish Hospital
Conclusions: On the whole, the children were previously healthy and are more than 1 year old. Respiratory symptoms were the leading cause of PICU admission, making respiratory support the principal therapy. Patients requiring mechanical ventilation showed deterioration on the first day of admission. These children seemed to require close monitoring, and multicenter studies are necessary.
Source: Pediatric Critical Care Medicine - August 1, 2020 Category: Pediatrics Tags: Online Brief Reports Source Type: research

Hospital-Acquired Infection in Pediatric Subjects With Congenital Heart Disease Postcardiotomy Supported on Extracorporeal Membrane Oxygenation*
Conclusions: Neonatal and pediatric subjects in this study have a high rate of acquired infection. Infants and children were at higher infection risk compared with neonatal subjects. There was not, however, a significant association between extracorporeal membrane oxygenation–related infection and survival to hospital discharge after propensity matching.
Source: Pediatric Critical Care Medicine - November 1, 2020 Category: Pediatrics Tags: Online Cardiac Intensive Care Source Type: research

The Use and Duration of Preintubation Respiratory Support Is Associated With Increased Mortality in Immunocompromised Children With Acute Respiratory Failure*
CONCLUSIONS: In IC pediatric patients, preintubation exposure to HFNC and/or NIPPV is associated with increased odds of PICU mortality, independent of illness severity. Longer duration of exposure to HFNC/NIPPV prior to IMV is associated with increased mortality in HCT patients.
Source: Critical Care Medicine - June 24, 2022 Category: Emergency Medicine Tags: Pediatric Critical Care Source Type: research

A Simple and Robust Bedside Model for Mortality Risk in Pediatric Patients With Acute Respiratory Distress Syndrome*
Objectives: Despite declining mortality, acute respiratory distress syndrome is still involved in up to one third of pediatric intensive care deaths. The recently convened Pediatric Acute Lung Injury Consensus Conference has outlined research priorities for the field, which include the need for accurate bedside risk stratification of patients. We aimed to develop a simple yet robust model of mortality risk among pediatric patients with acute respiratory distress syndrome to facilitate the targeted application of high-risk investigational therapies and stratification for enrollment in clinical trials. Design: Prospective, ...
Source: Pediatric Critical Care Medicine - October 1, 2016 Category: Pediatrics Tags: Feature Articles Source Type: research

Characteristics and Outcomes of Pediatric Patients Supported With Ventricular Assist Device—A Multi-Institutional Analysis*
Conclusions: The pediatric ventricular assist device experience continues to grow, with a significant increase in the number of patients undergoing ventricular assist device implantation and a higher proportion being discharged from hospital on ventricular assist device support in recent years. Underlying congenital heart disease, renal failure, sepsis, cerebrovascular accident, and extracorporeal membrane oxygenation are significantly associated with hospital mortality.
Source: Pediatric Critical Care Medicine - August 1, 2019 Category: Pediatrics Tags: Cardiac Intensive Care Source Type: research

Factors Associated With Neurobehavioral Complications in Pediatric Abdominal Organ Transplant Recipients Identified Using Computable Composite Definitions*
This study describes the occurrence of neurologic and behavioral complications (neurobehavioral complications) in pediatric abdominal solid organ transplant recipients. We examine the association of these complications with length of stay, mortality, and tacrolimus levels. Design: The electronic health record was interrogated for inpatient readmissions of pediatric abdominal solid organ transplant recipients from 2009 to 2017. A computable composite definition of neurobehavioral complication, defined using structured electronic data for neurologic and/or behavioral phenotypes, was created. Setting: Quaternary childre...
Source: Pediatric Critical Care Medicine - September 1, 2020 Category: Pediatrics Tags: Neurocritical Care Source Type: research

Risk of Mortality in Immunocompromised Children With Severe Sepsis and Septic Shock
Objectives: To assess the prevalence of immunocompromised diagnoses among children with severe sepsis and septic shock, and to determine the association between immunocompromised diagnoses and clinical outcomes after adjustment for demographics and illness severity. Design: Retrospective multicenter cohort study. Setting: Eighty-three centers in the Virtual Pediatric Systems database. Patients: Children with severe sepsis or septic shock admitted to a participating PICU between January 1, 2012, and December 31, 2016. Interventions: None. Measurements and Main Results: Across 83 centers, we identified 10,76...
Source: Critical Care Medicine - June 20, 2020 Category: Emergency Medicine Tags: Pediatric Critical Care Source Type: research

Risk Factors for Mortality in Critically Ill Children Requiring Renal Replacement Therapy*
Conclusions: Earlier renal replacement therapy initiation with respect to the development of severe acute kidney injury was associated with lower mortality in this cohort of critically ill children. Additionally, invasive mechanical ventilation at the time of renal replacement therapy initiation and a higher degree of fluid accumulation after initiating renal replacement therapy were associated with increased mortality.
Source: Pediatric Critical Care Medicine - November 1, 2019 Category: Pediatrics Tags: Renal Critical Care Source Type: research

Thromboelastography for evaluation of coagulopathy in nonbleeding patients with sepsis at intensive care unit admission
Conclusion: TEG could differentiate among normocoagulant, hypocoagulant, hypercoagulant states (unlike CCAs). Patients with septic shock had trend toward hypocoagulant state while those without shock had trend toward hypercoagulant state.
Source: Indian Journal of Critical Care Medicine - May 16, 2017 Category: Intensive Care Authors: Syed Nabeel Muzaffar Arvind Kumar Baronia Afzal Azim Anupam Verma Mohan Gurjar Banani Poddar Ratender Kumar Singh Source Type: research