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Post-operative quadriplegia as the initial manifestation of tumefactive multiple sclerosis
We present an unusual case of a patient with such manifestation and atypical lesions on brain magnetic resonance imaging. The patient was treated with methyl prednisolone pulse therapy and showed a dramatic response. Uncommon neurologic diseases can have very unusual presentations, which should be taken into consideration when encountered with such patients. Considering this fact will help physicians in better decision-making and proper treatment planning.
Source: Indian Journal of Critical Care Medicine - June 5, 2015 Category: Intensive Care Authors: Behzad MaghsoudiHossein HaddadPooya VatankhahAlireza RasekhiAbbas Rahimi Jaberi Source Type: research

Correlation of measurement of optic nerve sheath diameter with ultrasound and magnetic resonance imaging
Shakti Bedanta Mishra, Afzal Azim, Syed Nabeel MuzaffarIndian Journal of Critical Care Medicine 2015 19(10):624-624
Source: Indian Journal of Critical Care Medicine - October 9, 2015 Category: Intensive Care Authors: Shakti Bedanta MishraAfzal AzimSyed Nabeel Muzaffar Source Type: research

Hypercapnic respiratory failure in case of chiari 1.5 malformation: Case Report and review of the literature
We report a 35-year-old male who presented with acute hypercapnic respiratory failure (Type 2), without any preexisting neurological or respiratory abnormality. Analysis of blood gases in emergency revealed a pH of 7.12, pCO2of 132 mmHg, and arterial oxygen tension of 118 mm Hg. He was intubated and ventilated. Magnetic resonance imaging brain revealed herniation of the cerebellar tonsils along with brain stem and fourth ventricle. The patient underwent surgery and gradually weaned off. He was mobilized and discharged on day 6. Acute respiratory failure has not been reported with Chiari 1.5 malformation. The lesson to be l...
Source: Indian Journal of Critical Care Medicine - October 17, 2017 Category: Intensive Care Authors: Viralkumar M Vasani Subhas Kanti Konar S Satish Source Type: research

Acute leukoencephalopathy with restricted diffusion
Mahesh KamateIndian Journal of Critical Care Medicine 2018 22(7):519-523 Treatment and outcome of children with acute encephalopathy depend on the cause, prompt treatment of the underlying cause, and use of adequate supportive measures. Many novel causes of acute encephalopathy are emerging where lumbar puncture, computed tomography of the head, and routine biochemical testing can be normal such as acute disseminated encephalomyelitis and febrile infection-related refractory epilepsy syndrome. Magnetic resonance imaging (MRI) plays an important role in the workup of children with acute leukoencephalopathy. Despite this in...
Source: Indian Journal of Critical Care Medicine - July 17, 2018 Category: Intensive Care Authors: Mahesh Kamate Source Type: research

Dilemmas and challenges in treating seronegative autoimmune encephalitis in Indian children
Conclusion: The possibility of autoimmune encephalitis should be considered in patients with super-refractory status epilepticus. A large proportion of children with suspected AE may be “seronegative.” A trial of immunotherapy should be given to these children when there is a strong clinical suspicion of autoimmune encephalitis even in the absence of cerebrospinal fluid autoantibodies.
Source: Indian Journal of Critical Care Medicine - December 18, 2018 Category: Intensive Care Authors: Bandya Sahoo Mukesh Kumar Jain Reshmi Mishra Sibabratta Patnaik Source Type: research

Quantitative Magnetic Resonance Imaging of Bronchopulmonary Dysplasia in the NICU Environment.
CONCLUSIONS: Pulmonary MRI reveals quantifiable, significant differences between BPD patients, premature patients without BPD, and full-term controls; these methods could be implemented to individually phenotype disease, which may impact clinical care and predict future outcomes. PMID: 26186608 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - July 17, 2015 Category: Respiratory Medicine Authors: Walkup LL, Tkach JA, Higano NS, Thomen RP, Fain SB, Merhar SL, Fleck RJ, Amin RS, Woods JC Tags: Am J Respir Crit Care Med Source Type: research

Markers of vascular perturbation correlate with airway structural change in asthma.
Conclusions: Plasma VWFpp and P-selectin may be useful as surrogates of functional and structural defects that are evident on imaging. The results raise important questions about why VWFpp and P-selectin are associated specifically with different imaging abnormalities. PMID: 23855693 [PubMed - in process]
Source: American Journal of Respiratory and Critical Care Medicine - July 15, 2013 Category: Respiratory Medicine Authors: Johansson MW, Kruger SJ, Schiebler ML, Evans MD, Sorkness RL, Denlinger LC, Busse WW, Jarjour NN, Montgomery RR, Mosher DF, Fain SB Tags: Am J Respir Crit Care Med Source Type: research

Chronic Obstructive Pulmonary Disease and Cerebral Microbleeds: The Rotterdam Study.
Conclusions: Our findings are compatible with an increased risk of COPD on the development of cerebral microbleeds in deep or infratentorial locations. PMID: 23885754 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - July 25, 2013 Category: Respiratory Medicine Authors: Lahousse L, Vernooij MW, Darweesh SK, Akoudad S, Loth DW, Joos GF, Hofman A, Stricker BH, Ikram MA, Brusselle GG Tags: Am J Respir Crit Care Med Source Type: research

Brain Activity Associated with Placebo Suppression of the Urge-to-Cough in Humans.
Conclusions: Placebo-related decreases in urge-to-cough are accompanied by commensurate decreases in several brain regions activated during capsaicin inhalation, suggesting that beliefs about treatment can modify the central processing of inputs arising from the airways. The prefrontal cortex and posterior parietal cortex are likely to play an active role in the modification of airway sensory processing after administration of a placebo. PMID: 24093551 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - October 4, 2013 Category: Respiratory Medicine Authors: Leech J, Mazzone SB, Farrell MJ Tags: Am J Respir Crit Care Med Source Type: research

Quantification of Pulmonary Inflammation after Segmental Allergen Challenge Using TIRM Magnetic Resonance Imaging.
Conclusions: The MRI-based non-invasive TIRM score is a promising biomarker for the non-invasive detection of the inflammatory response after segmental allergen challenge in asthma patients and may serve to monitor the therapeutic effectiveness of novel anti-inflammatory drugs in future human trials. PMID: 24401150 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - January 8, 2014 Category: Respiratory Medicine Authors: Vogel-Claussen J, Renne J, Hinrichs J, Schönfeld C, Gutberlet M, Schaumann F, Winkler C, Faulenbach C, Krug N, Wacker FK, Hohlfeld JM Tags: Am J Respir Crit Care Med Source Type: research

Magnetic Resonance Imaging Detects Changes in Structure and Perfusion, and Response to Therapy in Early Cystic Fibrosis Lung Disease.
Conclusions: MRI detected abnormalities in lung structure and perfusion, and response to therapy for exacerbations in infants and preschool children with CF. These results support the development of MRI for non-invasive monitoring and as an endpoint in interventional trials for early CF lung disease. PMID: 24564281 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - February 24, 2014 Category: Respiratory Medicine Authors: Wielpütz MO, Puderbach M, Kopp-Schneider A, Stahl M, Fritzsching E, Sommerburg O, Ley S, Sumkauskaite M, Biederer J, Kauczor HU, Eichinger M, Mall MA Tags: Am J Respir Crit Care Med Source Type: research

Traffic Related Air Pollution and the Right Ventricle: The Multi-Ethnic Study of Atherosclerosis.
Conclusion: Higher levels of NO2 exposure were associated with greater RV mass and larger RV end-diastolic volume. PMID: 24593877 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - March 4, 2014 Category: Respiratory Medicine Authors: Leary PJ, Kaufman JD, Barr RG, Bluemke DA, Curl CL, Hough CL, Lima JA, Szpiro AA, Van Hee VC, Kawut SM Tags: Am J Respir Crit Care Med Source Type: research

Magnetic resonance imaging of inflammation in subjects with allergic asthma.
PMID: 24628308 [PubMed - in process]
Source: American Journal of Respiratory and Critical Care Medicine - March 15, 2014 Category: Respiratory Medicine Authors: Newell JD Tags: Am J Respir Crit Care Med Source Type: research

Metabolic Activity of the Tongue in Obstructive Sleep Apnea - A Novel Application of FDG-PET Imaging.
Conclusions: There was significantly reduced glucose uptake in the genioglossus of apneics in comparison to obese controls. The reduction in glucose uptake was likely secondary to alterations in tongue muscle fiber type or to chronic denervation. The reduced glucose uptake argues against the neuromuscular compensation hypothesis explaining the increase in tongue EMG activity in apneics. PMID: 24779734 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - April 29, 2014 Category: Respiratory Medicine Authors: Kim AM, Keenan BT, Jackson N, Chan EL, Staley B, Torigian DA, Alavi A, Schwab RJ Tags: Am J Respir Crit Care Med Source Type: research