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Therapy: Corticosteroid Therapy

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Total 30301 results found since Jan 2013.

Transcriptomic Signatures in Sepsis and a Differential Response to Steroids: From the VANISH Randomized Trial.
CONCLUSIONS: Transcriptomic profile at onset of septic shock was associated with response to corticosteroids. Those with the immuno-competent SRS2 endotype had significantly higher mortality when given corticosteroids compared to placebo. Clinical trial registration available at www.isrctn.com, ID ISRCTN20769191. PMID: 30365341 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - October 26, 2018 Category: Respiratory Medicine Authors: Antcliffe DB, Burnham KL, Al-Beidh F, Santhakumaran S, Brett SJ, Hinds CJ, Ashby D, Knight JC, Gordon AC Tags: Am J Respir Crit Care Med Source Type: research

Role of Biologics in Asthma.
This article will review the mechanism of action, indications, expected benefits, and side effects of each of the currently approved biologics for severe uncontrolled asthma, as well as discuss promising therapeutic targets for the future. PMID: 30525902 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - December 10, 2018 Category: Respiratory Medicine Authors: McGregor MC, Krings JG, Nair P, Castro M Tags: Am J Respir Crit Care Med Source Type: research

Multiview Cluster Analysis Identifies Variable Corticosteroid Response Phenotypes in Severe Asthma.
CONCLUSIONS: Our machine learning-based approaches provide new insights into mechanisms of CS responsiveness in asthma with the potential to improve disease treatment. PMID: 30682261 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - January 25, 2019 Category: Respiratory Medicine Authors: Wu W, Bang S, Bleecker ER, Castro M, Denlinger L, Erzurum SC, Fahy JV, Fitzpatrick AM, Gaston BM, Hastie AT, Israel E, Jarjour NN, Levy BD, Mauger DT, Meyers DA, Moore WC, Peters M, Phillips BR, Phipatanakul W, Sorkness RL, Wenzel SE Tags: Am J Respir Crit Care Med Source Type: research

Extracellular DNA, Neutrophil Extracellular Traps, and Inflammasome Activation in Severe Asthma.
CONCLUSION: High extracellular DNA levels in sputum marks a subset of patients with more severe asthma who have neutrophil extracellular traps and markers of inflammasome activation in their airways. PMID: 30888839 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - March 18, 2019 Category: Respiratory Medicine Authors: Lachowicz-Scroggins ME, Dunican EM, Charbit AR, Raymond W, Looney MR, Peters MC, Gordon ED, Woodruff PG, Lefrançais E, Phillips BR, Mauger DT, Comhair SA, Erzurum SC, Johansson MW, Jarjour NN, Coverstone AM, Castro M, Hastie AT, Bleecker ER, Fajt ML, Wen Tags: Am J Respir Crit Care Med Source Type: research

Reply to: Inhaled Corticosteroids and Adult Asthma.
PMID: 31339340 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - July 23, 2019 Category: Respiratory Medicine Authors: Beasley R, Harper J, Bird G, Maijers I, Weatherall M, Pavord ID Tags: Am J Respir Crit Care Med Source Type: research

Inhaled Corticosteroids and Adult Asthma.
PMID: 31339331 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - July 23, 2019 Category: Respiratory Medicine Authors: Boulet LP, Nair P Tags: Am J Respir Crit Care Med Source Type: research

Erratum: Multiview Cluster Analysis Identifies Variable Corticosteroid Response Phenotypes in Severe Asthma.
Authors: PMID: 31368796 [PubMed - in process]
Source: American Journal of Respiratory and Critical Care Medicine - July 31, 2019 Category: Respiratory Medicine Tags: Am J Respir Crit Care Med Source Type: research

Biomarkers Predictive of Exacerbations in the SPIROMICS and COPDGene Cohorts.
Conclusions: Blood biomarkers were significantly associated with the occurrence of exacerbations but were not robust between cohorts and added little to the predictive value of clinical covariates for exacerbations. PMID: 31891318 [PubMed - in process]
Source: American Journal of Respiratory and Critical Care Medicine - December 31, 2019 Category: Respiratory Medicine Authors: Keene JD, Jacobson S, Kechris K, Kinney GL, Foreman MG, Doerschuk CM, Make BJ, Curtis JL, Rennard SI, Barr RG, Bleecker ER, Kanner RE, Kleerup EC, Hansel NN, Woodruff PG, Han MK, Paine R, Martinez FJ, Bowler RP, O'Neal WK, COPDGene and SPIROMICS Investiga Tags: Am J Respir Crit Care Med Source Type: research

Inhaled Steroids, Circulating Eosinophils, Chronic Airway Infection and Pneumonia Risk in Chronic Obstructive Pulmonary Disease: A Network Analysis.
CONCLUSIONS: Less than 100 circulating eosinophils/L combined with the presence of CBI increase the risk of pneumonia in COPD patients treated with ICS. PMID: 31922913 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - January 9, 2020 Category: Respiratory Medicine Authors: Martinez-Garcia MA, Faner R, Oscullo G, la Rosa-Carrillo D, Soler-Cataluña JJ, Ballester M, Agusti A Tags: Am J Respir Crit Care Med Source Type: research

Thrombomodulin alfa for Acute Exacerbation of Idiopathic Pulmonary Fibrosis: A Randomized, Double-blind, Placebo-controlled Trial.
CONCLUSIONS: Thrombomodulin alfa did not improve the 90-day survival proportion. The present results suggest that the use of thrombomodulin alfa for the treatment of acute exacerbation of idiopathic pulmonary fibrosis not be recommended. Clinical trial registration available at www.clinicaltrials.gov, ID: NCT02739165. PMID: 31917621 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - January 8, 2020 Category: Respiratory Medicine Authors: Kondoh Y, Azuma A, Inoue Y, Ogura T, Sakamoto S, Tsushima K, Johkoh T, Fujimoto K, Ichikado K, Matsuzawa Y, Saito T, Kishi K, Tomii K, Sakamoto N, Aoshima M, Araya J, Izumi S, Arita M, Abe M, Yamauchi H, Shindoh J, Suda T, Okamoto M, Ebina M, Yamada Y, To Tags: Am J Respir Crit Care Med Source Type: research

Omalizumab for Aspirin-Hypersensitivity and Leukotriene Overproduction in Aspirin-Exacerbated Respiratory Disease: A Randomized Trial.
CONCLUSIONS: Omalizumab treatment inhibited urinary leukotriene E4 overproduction and upper/lower respiratory tract symptoms during oral aspirin challenge, resulting in aspirin tolerance in 62.5% of aspirin-exacerbated respiratory disease patients. Clinical trial registration available at https://www.umin.ac.jp/ctr/index.htm, ID: UMIN000018777. PMID: 32142372 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - March 5, 2020 Category: Respiratory Medicine Authors: Hayashi H, Fukutomi Y, Mitsui C, Kajiwara K, Watai K, Kamide Y, Nakamura Y, Hamada Y, Tomita Y, Sekiya K, Tsuburai T, Izuhara K, Wakahara K, Hashimoto N, Hasegawa Y, Taniguchi M Tags: Am J Respir Crit Care Med Source Type: research

Rapid Resolution of Severe Vaping Induced Acute Lipoid Pneumonia Following Corticosteroid Treatment.
PMID: 32142357 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - March 5, 2020 Category: Respiratory Medicine Authors: Alzghoul BN, Innabi A, Mukhtar F, Jantz MA Tags: Am J Respir Crit Care Med Source Type: research

Circulating MicroRNAs and Treatment Response in Childhood Asthma.
CONCLUSIONS: We identified two functional circulating miRNAs predictive of asthma ICS treatment response over time. PMID: 32272022 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - April 8, 2020 Category: Respiratory Medicine Authors: Li J, Panganiban R, Kho AT, McGeachie MJ, Farnam L, Chase RP, Weiss ST, Lu Q, Tantisira KG Tags: Am J Respir Crit Care Med Source Type: research

COVID-19 Related Genes in Sputum Cells in Asthma: Relationship to Demographic Features and Corticosteroids.
CONCLUSION: Higher expression of ACE2 and TMPRSS2 in males, African Americans, and patients with diabetes mellitus provides rationale for monitoring these asthma subgroups for poor COVID19 outcomes. The lower expression of ACE2 and TMPRSS2 with ICS use warrants prospective study of ICS use as a predictor of decreased susceptibility to SARS-CoV-2 infection and decreased COVID19 morbidity. This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives License 4.0 (http://creativecommons.org/licenses/by-nc-nd/4.0/). PMID: 32348692 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - April 28, 2020 Category: Respiratory Medicine Authors: Peters MC, Sajuthi S, Deford P, Christenson S, Rios CL, Montgomery MT, Woodruff PG, Mauger DT, Erzurum SC, Johansson MW, Denlinger LC, Jarjour NN, Castro M, Hastie AT, Moore W, Ortega VE, Bleecker ER, Wenzel SE, Israel E, Levy BD, Seibold MA, Fahy JV, Nat Tags: Am J Respir Crit Care Med Source Type: research

COVID-19, Asthma, and Inhaled Corticosteroids (ICS): Another Beneficial Effect of ICS?
PMID: 32437628 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - May 20, 2020 Category: Respiratory Medicine Authors: Maes T, Bracke K, Brusselle GG Tags: Am J Respir Crit Care Med Source Type: research