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Association of clinical characteristics with urine uromodulin in children with chronic kidney disease
ConclusionsAmong children with CKD, older age is significantly associated with lower Umod/Cr, independent of eGFR. Further studies are needed to comprehensively evaluate age-specific reference ranges for urine uromodulin and to evaluate the longitudinal relationship of uromodulin with both age and eGFR in children with CKD.Graphical abstractA higher resolution version of the Graphical abstract is available asSupplementary information
Source: Pediatric Nephrology - September 22, 2023 Category: Urology & Nephrology Source Type: research

Eyes sees what mind knows —a very rare cause of hydroureteronephrosis in a 12-year-old boy: Questions
Source: Pediatric Nephrology - September 22, 2023 Category: Urology & Nephrology Source Type: research

A typical clinical manifestation of atypical underlying diagnosis: Answers
Source: Pediatric Nephrology - September 22, 2023 Category: Urology & Nephrology Source Type: research

A typical clinical manifestation of atypical underlying diagnosis: Questions
Source: Pediatric Nephrology - September 22, 2023 Category: Urology & Nephrology Source Type: research

Eyes sees what mind knows —a very rare cause of hydroureteronephrosis in a 12-year-old boy: Answers
Source: Pediatric Nephrology - September 22, 2023 Category: Urology & Nephrology Source Type: research

A pediatric case of IgA nephropathy benefitting from targeted release formulation –budesonide
ConclusionOur case demonstrates that TRF-budesonide could be considered an effective second-line treatment in pediatric IgAN, particularly when a long course of steroids is necessary to control active inflammation. However, pediatric clinical trials to identify the correct dosage and tolerability of TRF-budesonide are urgently needed.
Source: Pediatric Nephrology - September 22, 2023 Category: Urology & Nephrology Source Type: research

Incidence of idiopathic nephrotic syndrome during the Covid-19 pandemic in the Paris area (France) and in the Netherlands
ConclusionsIncidence of INS before and during the Covid-19 pandemic was not different, but when schools were closed during lockdown, incidence was significantly lower. Interestingly, incidences of other respiratory viral infections were also reduced as was air pollution. Together, these results argue for a link between INS onset and viral infections and/or environmental factors.Graphical abstractA higher resolution version of the Graphical abstract is available asSupplementary information
Source: Pediatric Nephrology - September 22, 2023 Category: Urology & Nephrology Source Type: research

Favorable course of leptospirosis and hantavirus-induced acute tubulointerstitial nephritis under corticosteroid treatment
ConclusionsLeptospirosis and hantavirus associated ATIN share common clinical and biochemical features. Due to the low incidence in Europe these infectious causes of kidney dysfunction may be overlooked. Glucocorticoids may be considered in the management of ATIN.
Source: Pediatric Nephrology - September 22, 2023 Category: Urology & Nephrology Source Type: research

What is circulating factor disease and how is it currently explained?
AbstractNephrotic syndrome (NS) consists of the clinical triad of hypoalbuminaemia, high levels of proteinuria and oedema, and describes a heterogeneous group of disease processes with different underlying drivers. The existence of circulating factor disease (CFD) as a driver of NS has been epitomised by a subset of patients who exhibit disease recurrence after transplantation, alongside laboratory work. Several circulating factors have been proposed and studied, broadly grouped into protease components such as soluble urokinase-type plasminogen activator (suPAR), hemopexin (Hx) and calcium/calmodulin-serine protease kinas...
Source: Pediatric Nephrology - September 22, 2023 Category: Urology & Nephrology Source Type: research

A simplified protocol of regional citrate anticoagulation with phosphate-containing solutions in infants and children treated with continuous kidney replacement therapy
ConclusionsIn our experience, RCA with commercially available solutions was easily applied and managed in critically ill children, even in patients with low weight or with liver failure. Solutions containing phosphate and higher concentrations of magnesium and potassium allowed reduction of metabolic derangement during CKRT. Prolonged filter life was ensured with no detrimental effects on patients and reduced staff workload.Graphical abstractA higher resolution version of the Graphical abstract is available asSupplementary information
Source: Pediatric Nephrology - September 22, 2023 Category: Urology & Nephrology Source Type: research

Prevalence and risk factors of disordered eating behavior in youth with hypertension disorders
ConclusionsDEB prevalence is higher in youth with HTN disorders and comparable to other conditions requiring lifestyle counseling. Youth with HTN disorders may benefit from DEB screening.Graphical abstractA higher resolution version of the Graphical abstract is available asSupplementary information
Source: Pediatric Nephrology - September 22, 2023 Category: Urology & Nephrology Source Type: research

Identification of mutations in 15 nephrolithiasis-related genes leading to a molecular diagnosis in 85 Chinese pediatric patients
ConclusionsFifteen causative genes were detected in 85 Chinese pediatric patients with kidney stone diseases. The most common mutant genes, novel mutations, hotspot mutations, and genotype –phenotype correlations were also found. This study contributes to the understanding of genetic profiles and clinical courses in pediatric patients with hereditary nephrolithiasis.Graphical abstractA higher resolution version of the Graphical abstract is available asSupplementary information
Source: Pediatric Nephrology - September 22, 2023 Category: Urology & Nephrology Source Type: research

Non-surgical management in children with non-refluxing primary megaureter: a systematic review and meta-analysis
ConclusionsThe low pooled prevalence of secondary surgical intervention and high pooled prevalence of resolution may support the current non-surgical management in children with non-refluxing primary megaureter. However, these results should be interpreted cautiously due to the limited available body of evidence. Future studies should overcome existing limitations of imaging methods by using standardized, comparable criteria and report outcome parameters in a quantitative manner. This would allow more sufficient data synthesis to provide evidence-based recommendations for clinical decision-making and counseling.Systematic ...
Source: Pediatric Nephrology - September 22, 2023 Category: Urology & Nephrology Source Type: research

Clinical course and management of children with IgA vasculitis with nephritis
ConclusionsKidney outcomes over a limited follow-up period were favorable in a large cohort of children with IgAV. Immunosuppressive medications were used in those with more severe presentations and may have contributed to improved outcomes.Graphical abstractA higher resolution version of the Graphical abstract is available asSupplementary information
Source: Pediatric Nephrology - September 22, 2023 Category: Urology & Nephrology Source Type: research

Factors predicting the occurrence of disease-causing variants on next-generation sequencing in children with steroid-resistant nephrotic syndrome — implications for resource-constrained settings
ConclusionsWhile NGS-based genetic testing in SRNS is increasingly being incorporated in routine clinical practice the world over, the scenario is far from optimal in resource-limited settings. Our study highlights that resources for genetic testing in SRNS should be prioritized for patients with early age at disease onset and presence of family history. Larger studies composed of diverse multi-ethnic cohorts of patients with SRNS are required to further delineate the optimal strategy of genetic evaluation in resource-poor settings.Graphical abstractA higher resolution version of the Graphical abstract is available asSupplementary information
Source: Pediatric Nephrology - September 22, 2023 Category: Urology & Nephrology Source Type: research

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