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Male kidney-specific BMAL1 knockout mice are protected from Potassium-deficient, high salt diet-induced blood pressure increases
Am J Physiol Renal Physiol. 2023 Sep 14. doi: 10.1152/ajprenal.00126.2023. Online ahead of print.ABSTRACTThe circadian clock protein BMAL1 is a transcription factor that impacts kidney function, including blood pressure (BP) control. Previously, we showed that male, but not female, kidney-specific cadherin Cre positive BMAL1 knockout mice (KS-BMAL1 KO) exhibit lower BP compared to littermate controls. The goal of this study was to determine the BP phenotype and immune response in male KS-BMAL1 KO in response to a low potassium, high salt diet (LKHS). BP, renal inflammatory markers and immune cells were measured in male mic...
Source: Am J Physiol Renal P... - September 14, 2023 Category: Urology & Nephrology Authors: G Ryan Crislip Hannah M Costello Alexandria Juffre Kit-Yan Cheng I Jeanette Lynch Jermaine G Johnston Charles B Drucker Phillip Bratanatawira Annanya Agarwal Victor M Mendez Ryanne S Thelwell Lauren G Douma Charles S Wingo Abdel A Alli Yogesh M Scindia Mi Source Type: research

Impact of Sleep on Chronobiology of Micturition among Healthy Older Adults
Am J Physiol Renal Physiol. 2023 Aug 10. doi: 10.1152/ajprenal.00025.2023. Online ahead of print.ABSTRACTNocturia (waking to void) is prevalent among older adults. Disruption of the well-described circadian rhythm in urine production with higher nighttime urine output is its most common cause. In young adults, their circadian rhythm is modulated by the 24-hour secretory pattern of hormones that regulate salt and water excretion; including antidiuretic hormone (ADH), renin, angiotensin, aldosterone, and atrial natriuretic peptide (ANP). The pattern of hormone secretion is less clear in older adults. We investigated the effe...
Source: Am J Physiol Renal P... - August 10, 2023 Category: Urology & Nephrology Authors: Shachi Tyagi Neil M Resnick Becky D Clarkson Gehui Zhang Robert T Krafty Subashan Perera Arohan R Subramanya Daniel J Buysse Source Type: research

Metformin reduces insulin resistance and attenuates progressive renal injury in prepubertal obese Dahl salt-sensitive rats
Am J Physiol Renal Physiol. 2023 Jul 27. doi: 10.1152/ajprenal.00078.2023. Online ahead of print.ABSTRACTPrepubertal obesity (PPO) is currently an epidemic and is considered a major risk factor for renal injury. Previous studies have demonstrated that insulin resistance contributes to renal injury in obesity, independent of diabetes. However, studies examining the relationship between insulin resistance and renal injury in obese children are lacking. Recently, we reported that progressive renal injury in Dahl salt-sensitive leptin receptor mutant (SSLepRmutant) rats was associated with insulin resistance prior to puberty. ...
Source: Am J Physiol Renal P... - July 27, 2023 Category: Urology & Nephrology Authors: Ubong S Ekperikpe Sautan Mandal Stephen J Holt Jacori K Daniels Tyler D Johnson Jonita S Cooper Sarah M Safir Denise C Cornelius Jan M Williams Source Type: research

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