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Meningococcal factor H-binding protein: implications for disease susceptibility, virulence, and vaccines
Trends Microbiol. 2023 Mar 18:S0966-842X(23)00059-8. doi: 10.1016/j.tim.2023.02.011. Online ahead of print.ABSTRACTNeisseria meningitidis is a human-adapted pathogen that causes meningitis and sepsis worldwide. N. meningitidis factor H-binding protein (fHbp) provides a mechanism for immune evasion by binding human complement factor H (CFH) to protect it from complement-mediated killing. Here, we discuss features of fHbp which enable it to engage human CFH (hCFH), and the regulation of fHbp expression. Studies of host susceptibility and bacterial genome-wide association studies (GWAS) highlight the importance of the interac...
Source: Trends in Microbiology - March 20, 2023 Category: Microbiology Authors: Wearn-Xin Yee Grace Barnes Hayley Lavender Christoph M Tang Source Type: research