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Management: Food and Drug Administration (FDA)
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Total 117 results found since Jan 2013.
Efficacy of ketamine mouthwash in the management of oral and pharyngeal toxicity associated with head and neck chemoradiotherapy: protocol for a phase II, Simon's two-stage trial
BMJ Open. 2023 Apr 11;13(4):e064809. doi: 10.1136/bmjopen-2022-064809.ABSTRACTINTRODUCTION: Curative intent treatment of head and neck cancer (HNC) is frequently radiation therapy over 7 weeks with concurrent chemotherapy. This regimen is effective but carries a burden of toxicity leading to severe pain and treatment breaks portending inferior outcomes. Conventional palliation methods include opioids, anticonvulsants and local anaesthetics. Breakthrough toxicities are nevertheless ubiquitous and present an urgent unmet need. Ketamine is an inexpensive drug with mechanisms of analgesia outside the opioid pathway including N...
Source: Cancer Control - April 11, 2023 Category: Cancer & Oncology Authors: Daniel Koffler Jacob Eckstein Joseph Herman Diana Martins-Welch Nagashree Seetharamu Maged Ghaly Nina Kohn Louis Potters Douglas Frank Kevin Sullivan Bhupesh Parashar Source Type: research
A Clinical Trial of a Novel Electroencephalography Device as a Predictor of Postoperative Delirium
AANA J. 2023 Apr;91(2):125-129.ABSTRACTPostoperative delirium is a public health and research priority. The International Perioperative Neurotoxicity Working Group recommends baseline cognitive function be assessed for older patients prior to surgery and anesthesia. Perioperative cognitive screening tools trialed in anesthesia are not routinely incorporated into clinical practice related to validity, reliability, or practicality concerns. The ideal perioperative cognitive screening tool would be rapid; easily administrable; valid; reliable; automatically scored; void of language, cultural, and education bias; and cost-effi...
Source: AANA Journal - March 23, 2023 Category: Anesthesiology Authors: L Harold Barnwell Source Type: research
