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Total 20448 results found since Jan 2013.
Notice of Special Interest (NOSI): Next-Generation Approaches to Renal Replacement Therapy Including Vascular Access
Notice NOT-DK-23-015 from the NIH Guide for Grants and Contracts
Source: NIH Funding Opportunities (Notices, PA, RFA) - August 14, 2023 Category: Research Source Type: funding
Planning for Product Development Strategy (R34 Clinical Trial Not Allowed)
Funding Opportunity PAR-24-029 from the NIH Guide for Grants and Contracts. The purpose of this Notice of Funding Opportunity (NOFO) is to support the development of a comprehensive and well-defined product development strategy for next-generation treatments for HIV and HIV-associated comorbidities, coinfections and complication and preventive strategies for HIV, as well as facilitating the translation of research findings into drug products that enables submission of an Investigational New Drug (IND) application to the FDA.
Source: NIH Funding Opportunities (Notices, PA, RFA) - August 14, 2023 Category: Research Source Type: funding
Notice to Extend PA-18-793
Notice NOT-HS-23-019 from the NIH Guide for Grants and Contracts
Source: NIH Funding Opportunities (Notices, PA, RFA) - August 14, 2023 Category: Research Source Type: funding
Exploratory/Developmental Grants on Lifestyle Medicine Research Related to the World Trade Center Health Program (R21)
Funding Opportunity RFA-OH-24-002 from the NIH Guide for Grants and Contracts. NIOSH supports exploratory and developmental research projects (R21) that address issues related to diagnostic or treatment uncertainty with respect to individuals receiving monitoring and/or treatment under subtitle B of the James Zadroga 9/11 Health and Compensation Act of 2010 (Public Law 111347, as amended by Public Laws 114113, 11659 and 117-328). World Trade Center (WTC) responders, screening-eligible WTC survivors, and certified-eligible WTC survivors comprise the population targeted for the research project.
Source: NIH Funding Opportunities (Notices, PA, RFA) - August 14, 2023 Category: Research Source Type: funding
Valence delocalization in carbon-bridged mixed-valence iron complexes
Chemistry. 2023 Aug 13:e202301962. doi: 10.1002/chem.202301962. Online ahead of print.ABSTRACTThe carbide ligand in the iron-molybdenum cofactor (FeMoco) in nitrogenase bridges iron atoms in different oxidation states, yet it is difficult to discern its ability to mediate magnetic exchange interactions due to the structural complexity of the cofactor. Here, we describe two mixed-valent diiron complexes with C-based ketenylidene bridging ligands, and compare the carbon bridges with the more familiar sulfur bridges. The ground state of the [Fe2(m-CCO)2]+ complex with two carbon bridges (4) is S = 1/2 and is valence delocaliz...
Source: Chemistry - August 13, 2023 Category: Chemistry Authors: Majed S Fataftah Brandon Q Mercado Patrick L Holland Source Type: research
The mechanics of cephalic furrow formation in the Drosophila embryo
Biophys J. 2023 Aug 10:S0006-3495(23)00503-9. doi: 10.1016/j.bpj.2023.08.003. Online ahead of print.ABSTRACTCephalic furrow formation (CFF) is a major morphogenetic movement during gastrulation in Drosophila melanogaster embryos that gives rise to a deep, transitory epithelial invagination. Recent studies have identified the individual cell-shape changes that drive the initiation and progression phases of CFF; however, the underlying mechanics are not yet well understood. During the progression phase, the furrow deepens as columnar cells from both the anterior and posterior directions fold inwards rotating by 90°. To anal...
Source: Biophysical Journal - August 12, 2023 Category: Physics Authors: Redowan A Niloy Michael C Holcomb Jeffrey H Thomas Jerzy Blawzdziewicz Source Type: research
Neural and Non-Neural Mechanisms Underlying Gait as a Preclinical Marker for Alzheimers Disease and Alzheimers Disease-Related Dementias (R01 Clinical Trial Optional)
Funding Opportunity RFA-AG-24-041 from the NIH Guide for Grants and Contracts. The purpose of this Notice of Funding Opportunity (NOFO) is to invite applications that investigate the neural and/or non-neural mechanisms that underlie the association between gait and cognition in aging and Alzheimer's disease and Alzheimer's disease-related dementias (AD/ADRD). Elucidating these mechanisms would help inform the potential use of changes gait as an early biomarker of AD/ADRD or inform the design of early interventions for AD/ADRD. To achieve these goals, it will be necessary to facilitate a team science approach by bringing e...
Source: NIH Funding Opportunities (Notices, PA, RFA) - August 11, 2023 Category: Research Source Type: funding
NIH Brain Development Cohorts (NBDC) Biospecimen Access (X01 Clinical Trial Not Allowed)
Funding Opportunity PAR-23-229 from the NIH Guide for Grants and Contracts. The Adolescent Brain Cognitive Development (ABCD) Study is the largest longitudinal study of brain development and child health collecting data from more than 11,000 children across the U.S. beginning when they are 9-10 years old and continuing for a decade. In addition to behavioral assessments, youth undergo neuroimaging and provide biospecimens, including saliva for hormone analysis, urine and hair for substance use and exposure, deciduous teeth for environmental exposure, and blood for genetic analysis and metabolic and hematologic assays. Thi...
Source: NIH Funding Opportunities (Notices, PA, RFA) - August 11, 2023 Category: Research Source Type: funding
Community-Engaged Health Equity Research in Neuroscience Initiative (R34 CT Not Allowed)
Funding Opportunity RFA-NS-24-007 from the NIH Guide for Grants and Contracts. This NOFO solicits applications for planning grants to assess feasibility and/or determine best practices to conduct community-engaged health equity research in neurological disorders with populations that experience health disparities (HDPs). If successful, these planning grants would support, enable and/or lay the groundwork for future clinical studies or trials.In addition to posing a research question related to addressing health disparities in neurological disorders, applicants must also be filling a gap in 1) Engagement with one or more H...
Source: NIH Funding Opportunities (Notices, PA, RFA) - August 11, 2023 Category: Research Source Type: funding
Soluble wild-type ACE2 molecules inhibit newer SARS-CoV-2 variants and are a potential antiviral strategy to mitigate disease severity in COVID-19
Clin Exp Immunol. 2023 Aug 11:uxad096. doi: 10.1093/cei/uxad096. Online ahead of print.ABSTRACTSARS-CoV-2, the virus responsible for COVID-19, has caused havoc around the world. While several COVID-19 vaccines and drugs have been authorised for use, these antiviral drugs remain beyond the reach of most low- and middle-income countries. Rapid viral evolution is reducing the efficacy of vaccines and monoclonal antibodies and contributing to deaths of some fully vaccinated persons. Others with normal immunity may have chosen not be vaccinated and remain at risk if they contract the infection. Vaccines may not protect some imm...
Source: Clinical and Developmental Immunology - August 11, 2023 Category: Allergy & Immunology Authors: Rohan Ameratunga Emily Mears Euphemia Leung Russell Snell See-Tarn Woon William Kelton Natalie Medlicott Anthony Jordan William Abbott Richard Steele William Rolleston Hilary Longhurst Klaus Lehnert Source Type: research
Notice of Correction to Other Submission Requirements and Information in PAR-22-181 "Research Opportunities for New and "At-Risk" Investigators to Promote Workforce Diversity (R01 Clinical Trial Optional)"
Notice NOT-NS-23-106 from the NIH Guide for Grants and Contracts
Source: NIH Funding Opportunities (Notices, PA, RFA) - August 11, 2023 Category: Research Source Type: funding
