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Management: Partnerships
Nutrition: Calcium
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Ca < sup > 2+ < /sup > Release or Ca < sup > 2+ < /sup > Entry, that is the Question: What Governs Ca < sup > 2+ < /sup > Oscillations in Pancreatic Beta Cells?
Am J Physiol Endocrinol Metab. 2023 Apr 19. doi: 10.1152/ajpendo.00030.2023. Online ahead of print.ABSTRACTThe standard model for Ca2+ oscillations in insulin-secreting pancreatic beta cells centers on Ca2+ entry through voltage-activated Ca2+ channels. These work in combination with ATP-dependent K+ channels, which are the bridge between the metabolic state of the cells and plasma membrane potential. This partnership underlies the ability of the beta cells to secrete insulin appropriately on a minute-to-minute time scale to control whole-body plasma glucose. Though this model, developed over more than 40 years through man...
Source: Am J Physiol Endocri... - April 19, 2023 Category: Endocrinology Authors: Patrick A Fletcher Benjamin Thompson Chant é Liu Richard Bertram Leslie S Satin Arthur S Sherman Source Type: research
