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Timeliness of childhood vaccination in England: A population-based cohort study
We described vaccine uptake for representative antigens (pertussis, pneumococcus, measles) by age in days and stratified by ethnicity, region and birth cohort. Alluvial diagrams were used to illustrate common journeys through the vaccination schedule, and we applied survival analysis using accelerated failure time models (AFT) to predict age of vaccine receipt based on timing of previous doses.RESULTS: 573,015 children were followed up until their fifth birthday, when they had 90.16 % coverage for two doses of measles, mumps, rubella (MMR) vaccine and 88.78% coverage for four doses of diphtheria, tetanus, pertussis (DTP) v...
Source: Vaccine - August 13, 2023 Category: Allergy & Immunology Authors: Anne M Suffel Jemma L Walker Elizabeth Williamson Helen I McDonald Charlotte Warren-Gash Source Type: research

Safety of tetanus, diphtheria, acellular pertussis (Tdap) vaccination during pregnancy
The objective of this study was to evaluate the safety of prenatal tetanus, diphtheria, acellular pertussis (Tdap) vaccination. This cohort study was conducted among pregnant members at Kaiser Permanente Southern California (KPSC). The exposed cohort consisted of women who received Tdap vaccine on or after the 27th week of pregnancy between January 2018 and January 2019. The unexposed cohort consisted of matched women who were pregnant between January 2012 and December 2014 and were not vaccinated with any Tdap vaccine throughout their pregnancy. Maternal and infant characteristics and pre-specified endpoints were collecte...
Source: Vaccine - June 18, 2022 Category: Allergy & Immunology Authors: Hung Fu Tseng Lina S Sy Bradley K Ackerson Gina S Lee Yi Luo Ana Florea Tracy Becerra-Culqui Sara Y Tartof Yun Tian Christine Taylor Laura Campora Maria Angeles Ceregido Anastasia Kuznetsova Jean-Etienne Poirrier Dominique Rosillon Laura Valdes Brigitte C Source Type: research

Exploring electronic health records to estimate the extent of catch-up immunisation and factors associated with under-immunisation among refugees and asylum seekers in south east Queensland
CONCLUSION: This study indicates that the broader group of immigrants, and in particular refugees and asylum seekers, do not represent a homogenous group in terms of immunisation coverage, and that each cohort should be carefully considered during immunisation interventions and strategies. This will be particularly important during targeted health promotions and future immunisation programs in this cohort.PMID:34556368 | DOI:10.1016/j.vaccine.2021.09.026
Source: Vaccine - September 24, 2021 Category: Allergy & Immunology Authors: Mercy Moraa Nyanchoga Patricia Lee Gaery Barbery Source Type: research

DrugWAS: Drug-wide association studies for COVID-19 drug repurposing
In conclusion, this cohort study leveraged EHR data to identify a list of drugs that could be repurposed to improve COVID-19 outcomes. Further randomized clinical trials are needed to investigate the efficacy of the proposed drugs.PMID:34314511 | DOI:10.1002/cpt.2376
Source: Clinical Pharmacology and Therapeutics - July 27, 2021 Category: Drugs & Pharmacology Authors: Cosmin A Bejan Katherine N Cahill Patrick J Staso Leena Choi Josh F Peterson Elizabeth J Phillips Source Type: research

Patient and clinician factors associated with uptake of the human papillomavirus (HPV) vaccine among adolescent patients of a primary care network
CONCLUSION: HPV vaccine uptake varied by patient characteristics, heath care utilization and primary care clinician specialty. These findings may inform future evidence-based interventions aimed at increasing HPV vaccine uptake among adolescents by targeting patient sub-groups and reducing missed opportunities for vaccination.PMID:34023133 | DOI:10.1016/j.vaccine.2021.04.055
Source: Vaccine - May 23, 2021 Category: Allergy & Immunology Authors: Julie H T Dang Susan L Stewart Dean A Blumberg Hector P Rodriguez Moon S Chen Source Type: research