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Flow diversion with Pipeline Embolic Device as treatment of subarachnoid hemorrhage secondary to blister aneurysms: dual-center experience and review of the literature
Conclusions Repair of ruptured BA with PED may be a safe and durable option.
Source: Journal of NeuroInterventional Surgery - December 13, 2016 Category: Neurosurgery Authors: Linfante, I., Mayich, M., Sonig, A., Fujimoto, J., Siddiqui, A., Dabus, G. Tags: Hemorrhagic stroke Source Type: research

E-067 Endovascular Approach in the Repair of the Middle Cerebral Artery Aneurysm Including Those with Wide Neck and Complex in Morphology-A Case Series
ConclusionsEndovascular repair of the MCA aneurysm inclosing those with wide neck and complex are not only safe and feasible, but associated with high long-term functional outcome. Therefore, endovascular options must be offered to patients prior to surgical clipping of a MCA aneurysm. Further study may be warranted.DisclosuresY. Lodi: None. V. Reddy: None.
Source: Journal of NeuroInterventional Surgery - July 28, 2016 Category: Neurosurgery Authors: Lodi, Y., Reddy, V. Tags: Electronic poster abstracts Source Type: research

Use of flow-diverting stents as salvage treatment following failed stent-assisted embolization of intracranial aneurysms
We report our experience using flow-diverting stents in the repair of 25 aneurysms for which stent-assisted embolization had failed. Nineteen (76%) of these aneurysms at the 12-month follow-up showed improved Raymond class occlusion, with 38% being completely occluded, and all aneurysms demonstrated decreased filling. One patient developed a moderate permanent neurologic deficit. Appropriate stent sizing, proximal and distal construct coverage, and preventing flow diverter deployment between the previously deployed stent struts are important considerations to ensure wall apposition and prevention of endoleak. Flow diverter...
Source: Journal of NeuroInterventional Surgery - June 13, 2016 Category: Neurosurgery Authors: Heiferman, D. M., Billingsley, J. T., Kasliwal, M. K., Johnson, A. K., Keigher, K. M., Frudit, M. E., Moftakhar, R., Lopes, D. K. Tags: Hemorrhagic stroke Source Type: research

Groin complications in endovascular mechanical thrombectomy for acute ischemic stroke: a 10-year single center experience
Conclusions These findings suggest that concerns for groin complications should not preclude the use of BGCs and large-bore sheaths in mechanical thrombectomy for acute ischemic stroke.
Source: Journal of NeuroInterventional Surgery - May 12, 2016 Category: Neurosurgery Authors: Shah, V. A., Martin, C. O., Hawkins, A. M., Holloway, W. E., Junna, S., Akhtar, N. Tags: Open access, Ischemic stroke Source Type: research

Old benefit as much as young patients with stroke from high-intensity neurorehabilitation: cohort analysis
Conclusions Old and even very old patients with stroke benefit from specialised inpatient neurorehabilitation and high amounts of therapy in the same degree as younger patients. Contrary to current clinical practice, old age should not be a criterion against admission to a neurorehabilitation unit following acute stroke treatment.
Source: Journal of Neurology, Neurosurgery and Psychiatry - April 13, 2016 Category: Neurosurgery Authors: Knecht, S., Rossmüller, J., Unrath, M., Stephan, K.-M., Berger, K., Studer, B. Tags: Open access, Stroke Cerebrovascular disease Source Type: research

Recent Progress in Endothelial Progenitor Cell Culture Systems: Potential for Stroke Therapy.
Authors: Takizawa S, Nagata E, Nakayama T, Masuda H, Asahara T Abstract Endothelial progenitor cells (EPCs) participate in endothelial repair and angiogenesis due to their abilities to differentiate into endothelial cells and to secrete protective cytokines and growth factors. Consequently, there is considerable interest in cell therapy with EPCs isolated from peripheral blood to treat various ischemic injuries. Quality and quantity-controlled culture systems to obtain mononuclear cells enriched in EPCs with well-defined angiogenic and anti-inflammatory phenotypes have recently been developed, and increasing eviden...
Source: Neurologia Medico-Chirurgica - April 6, 2016 Category: Neurosurgery Tags: Neurol Med Chir (Tokyo) Source Type: research

Incidence and morbidity of craniocervical arterial dissections in atraumatic subarachnoid hemorrhage patients who underwent aneurysmal repair
Conclusions Our study indicates an annual increase in the incidence of CCADs in patients admitted with SAH who require aneurysmal repair. More than two-thirds of these patients that developed CCADs had undergone endovascular coiling repair. A diagnosis of CCAD increased the length of hospital stay but had no statistically significant association with mortality in this patient population.
Source: Journal of NeuroInterventional Surgery - September 13, 2015 Category: Neurosurgery Authors: Carr, K., Rincon, F., Maltenfort, M., Birnbaum, L., Dengler, B., Rodriguez, M., Seifi, A. Tags: Editor''s choice, Hemorrhagic stroke Source Type: research

Stem Cell Transplantation Enhances Endogenous Brain Repair after Experimental Stroke.
Authors: Horie N, Hiu T, Nagata I Abstract Stem cell transplantation for stroke treatment has been a promising therapy in small and large animal models, and many clinical trials are ongoing to establish this strategy in a clinical setting. However, the mechanism underlying functional recovery after stem cell transplantation has not been fully established and there is still a need to determine the ideal subset of stem cells for such therapy. We herein reviewed the recent evidences showing the underlying mechanism of functional recovery after cell transplantation, focusing on endogenous brain repair. First, angiogene...
Source: Neurologia Medico-Chirurgica - August 5, 2015 Category: Neurosurgery Tags: Neurol Med Chir (Tokyo) Source Type: research

O-027 the barrel vrd™ vascular reconstruction device for the treatment of wide-neck bifurcation aneurysms
ConclusionsThe results demonstrate that the Barrel VRD device is new, effective tool for the endovascular treatment of wide neck bifurcation aneurysms. The main advantage of the Barrel VRD™ is to avoid the use of 2 stents in a Y-configuration for bifurcation aneurysm neck reconstruction.DisclosuresM. Piotin: 2; C; Covidien, Microvention, Stryker. 4; C; Lazarus Effect. J. Berge: None. F. Turjman: None. R. Blanc: None.
Source: Journal of NeuroInterventional Surgery - July 26, 2015 Category: Neurosurgery Authors: Piotin, M., Berge, J., Turjman, F., Blanc, R. Tags: SNIS 12th Annual Meeting Oral Abstracts Source Type: research

Stem cell transplantation enhances endogenous brain repair after experimental stroke.
Authors: Horie N, Hiu T, Nagata I Abstract Stem cell transplantation for stroke treatment has been a promising therapy in small and large animal models, and many clinical trials are ongoing to establish this strategy in a clinical setting. However, the mechanism underlying functional recovery after stem cell transplantation has not been fully established and there is still a need to determine the ideal subset of stem cells for such therapy. We herein reviewed the recent evidences showing the underlying mechanism of functional recovery after cell transplantation, focusing on endogenous brain repair. First, angiogene...
Source: Neurologia Medico-Chirurgica - June 3, 2015 Category: Neurosurgery Tags: Neurol Med Chir (Tokyo) Source Type: research

Use of thromboelastography to tailor dual-antiplatelet therapy in patients undergoing treatment of intracranial aneurysms with the Pipeline embolization device
Conclusions Platelet function testing with TEG altered our DAT induction strategy in a significant number of cases. No hemorrhagic or disabling thromboembolic complications were seen in this series. Future studies should compare methods of platelet function testing and, possibly, no platelet function testing in neurovascular patients undergoing flow diversion and/or stent-assisted treatment of intracranial aneurysms.
Source: Journal of NeuroInterventional Surgery - May 14, 2015 Category: Neurosurgery Authors: McTaggart, R. A., Choudhri, O. A., Marcellus, M. L., Brennan, T., Steinberg, G. K., Dodd, R. L., Do, H. M., Marks, M. P. Tags: Hemorrhagic stroke Source Type: research

Endovascular reconstruction for progressively worsening carotid artery dissection
Conclusions Endovascular stent reconstruction for the treatment of selected patients with progressively worsening carotid dissection despite medical management is feasible with acceptable immediate and long-term clinical and radiographic outcomes. To be able to draw more robust conclusions, further evaluation with larger number of patients and longer follow-up is needed.
Source: Journal of NeuroInterventional Surgery - December 11, 2014 Category: Neurosurgery Authors: Asif, K. S., Lazzaro, M. A., Teleb, M. S., Fitzsimmons, B.-F., Lynch, J., Zaidat, O. Tags: Ischemic stroke Source Type: research

Final results of the multicenter, prospective Axium MicroFX for Endovascular Repair of IntraCranial Aneurysm Study (AMERICA)
Conclusions In this prospective, multicenter series of 100 aneurysms treated with Axium MicroFX PGLA (polyglycolic/polylactic acid) coils, 3–6 month angiographic occlusion and clinical outcomes were excellent. This study suggests that Axium MicroFX PGLA coils are safe and effective in the treatment of intracranial aneurysms.
Source: Journal of NeuroInterventional Surgery - December 11, 2014 Category: Neurosurgery Authors: Fargen, K. M., Blackburn, S., Deshaies, E. M., Carpenter, J. S., Jabbour, P., Mack, W. J., Rai, A. T., Siddiqui, A. H., Turner, R. D., Mocco, J. Tags: Hemorrhagic stroke Source Type: research

Minimally invasive and rapid surgical embolectomy (MIRSE) as rescue treatment following failed endovascular recanalization for acute ischemic stroke
Conclusions A MIRSE can be an effective rescue treatment after the failure of endovascular recanalization therapies for acute occlusion of proximal intracranial arteries if the patient is within the therapeutic time window.
Source: Acta Neurochirurgica - October 14, 2014 Category: Neurosurgery Source Type: research

Is aneurysm repair justified for the patients aged 80 or older after aneurysmal subarachnoid hemorrhage?
Conclusions Better prognosis was obtained when ruptured aneurysm was repaired in the elderly than it was treated conservatively. From the results of this study, we should not hesitate to offer the definitive surgery for the elderly with aSAH.
Source: Journal of NeuroInterventional Surgery - October 7, 2014 Category: Neurosurgery Authors: Sadamasa, N., Koyanagi, M., Fukuda, H., Chin, M., Handa, A., Yamagata, S. Tags: Hemorrhagic stroke Source Type: research

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