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Targeting Microglial Activation in Stroke Therapy: Pharmacological Tools and Gender Effects.
Abstract Ischemic stroke is caused by critical reductions in blood flow to a part of brain or spinal cord. Microglia are the resident immune cells of the central nervous system, and they respond to stroke by assuming an activated phenotype that releases cytotoxic cytokines, reactive oxygen species, proteases, and other factors. This acute, innate immune response may be teleologically adapted to limit infection, but in stroke this response can exacerbate injury by further damaging or killing nearby neurons and other cell types and by recruiting infiltration of circulating cytotoxic immune cells. The microglial resp...
Source: Current Medicinal Chemistry - December 28, 2013 Category: Chemistry Authors: Chen Y, Won SJ, Xu Y, Swanson RA Tags: Curr Med Chem Source Type: research