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Specialty: Neurosurgery

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Total 6508 results found since Jan 2013.

The role of hippocampal pathology in post-stroke cognitive impairment
Background Cognitive impairment is common following cerebrovascular disease. Recently it has been associated with hippocampal ultra-structural damage in stroke survivors. We aim to study the long-term cognitive profile of patients after ischaemic stroke and characterise the cognitive behaviours associated with any dynamic changes in the structure, function and metabolism of the hippocampi, using multimodal MRI at 3Tesla. Methods We are conducting a dual-centre study to investigate the predictive value of diagnostic MRI and resting-state fMRI based on observing natural history of cognitive function following stroke (at bas...
Source: Journal of Neurology, Neurosurgery and Psychiatry - November 14, 2016 Category: Neurosurgery Authors: Hosseini, A. A., Ispoglou, S., Hayton, T., Evans, R., Wilson, M., Sawlani, V., Rotshtein, P., Auer, D. P. Tags: Stroke, Memory disorders (psychiatry), Radiology, Radiology (diagnostics) ABN Annual Meeting, 17-19 May 2016, The Brighton Centre, Brighton Source Type: research

Mechanical thrombectomy for anterior circulation stroke: 5-year experience in a statewide service with differences in pretreatment time metrics across two hospitals sites
Conclusions Outcomes similar to randomized controlled trials are attainable in ‘real-world’ settings. Workflow time metrics were independent predictors of clinical outcome, and differed between the two hospitals owing to site-specific organizational differences.
Source: Journal of NeuroInterventional Surgery - May 30, 2017 Category: Neurosurgery Authors: Kabra, R., Phillips, T. J., Saw, J.-L., Phatouros, C. C., Singh, T. P., Hankey, G. J., Blacker, D., Ghia, D., Prentice, D., McAuliffe, W. Tags: Ischemic stroke Source Type: research

Differential effect of mechanical thrombectomy and intravenous thrombolysis in atrial fibrillation associated stroke
Conclusions In patients treated with MT, comorbid AF is associated with faster procedural time, fewer passes, and increased rates of first pass success without increased risk of intracranial hemorrhage or worse functional outcomes. These results are in contrast to the increased hemorrhage rates and worse functional outcomes observed in AF associated stroke treated with supportive care and or IVT. These data suggest that MT negates the AF penalty in ischemic stroke.
Source: Journal of NeuroInterventional Surgery - September 15, 2021 Category: Neurosurgery Authors: Akbik, F., Alawieh, A., Cawley, C. M., Howard, B. M., Tong, F. C., Nahab, F., Saad, H., Dimisko, L., Mustroph, C., Samuels, O. B., Pradilla, G., Maier, I., Goyal, N., Starke, R. M., Rai, A., Fargen, K. M., Psychogios, M. N., Jabbour, P., De Leacy, R., Gil Tags: Ischemic stroke Source Type: research

Thromboelastography predicts dual antiplatelet therapy-related hemorrhage in patients with acute ischemic stroke
Conclusions Monitoring changes of TEG parameters helps to guide personalized DAPT for patients with ischemic stroke. A 30–82.3% range of ADP% is recommended for DAPT treatment.
Source: Journal of NeuroInterventional Surgery - June 16, 2022 Category: Neurosurgery Authors: He, D., Guo, Y., Zhang, Y., Zhao, J., Wu, L., Yu, Z., Qu, W., Luo, X. Tags: Open access, Ischemic stroke Source Type: research

Hyperglycemic control in acute ischemic stroke patients undergoing endovascular treatment: post hoc analysis of the Stroke Hyperglycemia Insulin Network Effort trial
Conclusion We did not identify any beneficial effect of intensive glucose reduction on rates of death or favorable outcomes at 90 days among acute ischemic stroke patients undergoing endovascular treatment.
Source: Journal of NeuroInterventional Surgery - March 14, 2023 Category: Neurosurgery Authors: Bains, N. K., Huang, W., French, B. R., Siddiq, F., Gomez, C. R., Qureshi, A. I. Tags: Ischemic stroke Source Type: research

Transferring neurointerventionalists saves time compared with interhospital transfer of stroke patients for endovascular thrombectomy: a collaborative pooled analysis of 1001 patients (EVEREST)
Conclusions This pooled analysis of the EVEREST collaboration adds evidence that performing EVT at external hospitals can save time compared with drip and ship across various geographical regions. We encourage conducting randomized controlled trials comparing both triage concepts.
Source: Journal of NeuroInterventional Surgery - May 16, 2023 Category: Neurosurgery Authors: Seker, F., Fifi, J. T., Morey, J. R., Osanai, T., Oki, S., Brekenfeld, C., Fiehler, J., Bendszus, M., Möhlenbruch, M. A. Tags: Open access, Ischemic stroke Source Type: research

Travel time and distance for bypass and non-bypass routing of stroke patients in the USA
Conclusions Bypass routing offers modest travel time benefits for LVO patients and incurs modest penalties for non-LVO patients. Differences are greatest in rural areas. A majority of Americans live in areas for which current guidelines recommend bypass.
Source: Journal of NeuroInterventional Surgery - June 16, 2023 Category: Neurosurgery Authors: Yu, C. Y., Panagos, P. D., Kansagra, A. P. Tags: Ischemic stroke Source Type: research

Stroke: mechanisms, stratification and implementation
This issue of JNNP has been given over to considering current directions in stroke research. It was not so long ago that neurologists were unsure whether to embrace the specialty of stroke as one of their own. Whichever way you look at it though, stroke is a disease that starts in the vascular system but leads to focal brain damage with behavioural consequences. There is enough to keep neurologists, neurosurgeons and indeed psychiatrists involved. The incidence of stroke has decreased over recent decades1 2 largely driven by improvements in the management of risk factors but stroke is still, and perhaps always will be, a m...
Source: Journal of Neurology, Neurosurgery and Psychiatry - February 15, 2013 Category: Neurosurgery Authors: Ward, N. S. Tags: Long term care, Drugs: CNS (not psychiatric), Stroke, Ophthalmology, Memory disorders (psychiatry) Editorial commentaries Source Type: research

Return to work after stroke: the role of cognitive deficits
Stroke is recognised as a leading cause of the global disease burden. In high-income countries, 20% of strokes occur in people of working age, many of whom are in paid employment.1 This figure is probably much higher in low-to middle-income countries where the average age of onset of stroke is lower. Employment is one of the most important social roles that a person fulfills and not working has negative impacts on one's overall quality of life, health, finances, social isolation and self-efficacy. Because younger adults are responsible for generating income and supporting family members, returning to work is a key goal in ...
Source: Journal of Neurology, Neurosurgery and Psychiatry - February 15, 2013 Category: Neurosurgery Authors: Arauz, A. Tags: Stroke, Ischaemic heart disease Editorial commentaries Source Type: research

Could saccadic function be a useful marker of stroke recovery?
There is no pharmacological therapy presently available to improve the long-term recovery from acute ischaemic stroke. Either there hasn't yet been a suitable treatment trialled, or the tools for measuring recovery have not been sensitive enough. It is critical therefore to continue to search for robust objective markers of stroke recovery in parallel with the push for drug discovery. Can saccade measures provide such a marker? Dong et al report that in a limited number of mild stroke patients, saccadic parameters that probe cognitive function, especially errors of inhibition during antisaccade and memory-guided paradigms,...
Source: Journal of Neurology, Neurosurgery and Psychiatry - February 15, 2013 Category: Neurosurgery Authors: Anderson, T. Tags: Other rehabilitative therapies, Genetics, Immunology (including allergy), Brain stem / cerebellum, Drugs: CNS (not psychiatric), Movement disorders (other than Parkinsons), Multiple sclerosis, Parkinson's disease, Spinal cord, Stroke, Ophthalmology, Memor Source Type: research

Is the outpatient management of acute minor stroke feasible and safe?
Paul et al1 have assessed the clinical outcomes, early hospital admission rates and hospital care costs in clinic referred and hospital referred minor stroke patients in a prospective population based study. They did not find significant differences in the 30 day admission rate in clinic patients compared with the 30 day readmission rate after discharge in hospital treated patients (16/237 vs 9/150). The 30 day recurrent stroke risk in patients with minor ischaemic stroke was also similar in those discharged from clinic compared with hospital patients (3.8% vs 5.3%; p=0.61). The recurrent stroke risk remained similar in pa...
Source: Journal of Neurology, Neurosurgery and Psychiatry - February 15, 2013 Category: Neurosurgery Authors: Csiba, L. Tags: Epilepsy and seizures, Stroke, Hypertension Editorial commentaries Source Type: research

What drives the increasing utilisation of hemicraniectomy in acute ischaemic stroke?
Conclusion Utilisation of hemicraniectomy in the USA has increased significantly, in line with compelling results from European clinical trials. Early transfer of patients with malignant infarctions to urban teaching centres could potentially extend the survival benefit to a larger population.
Source: Journal of Neurology, Neurosurgery and Psychiatry - June 9, 2013 Category: Neurosurgery Authors: Bhattacharya, P., Kansara, A., Chaturvedi, S., Coplin, W. Tags: Stroke Cerebrovascular disease Source Type: research

Seizures after decompressive hemicraniectomy for ischaemic stroke
Conclusions In this case series, patients were at high risk of developing seizures after malignant MCA stroke with DHC, especially after cranioplasty. Assuming these findings are replicated, means should be sought to reduce the occurrence of this complication.
Source: Journal of Neurology, Neurosurgery and Psychiatry - June 10, 2014 Category: Neurosurgery Authors: Creutzfeldt, C. J., Tirschwell, D. L., Kim, L. J., Schubert, G. B., Longstreth, W. T., Becker, K. J. Tags: Epilepsy and seizures, Stroke Cerebrovascular disease Source Type: research

Degree of blood pressure reduction and recurrent stroke: the PROGRESS trial
Conclusions The present analysis provided no evidence of an increase in recurrent stroke associated with larger reductions in SBP produced by treatment among patients with cerebrovascular disease.
Source: Journal of Neurology, Neurosurgery and Psychiatry - October 17, 2014 Category: Neurosurgery Authors: Arima, H., Anderson, C., Omae, T., Woodward, M., MacMahon, S., Mancia, G., Bousser, M.-G., Tzourio, C., Harrap, S., Liu, L., Neal, B., Chalmers, J., for the PROGRESS Collaborative Group Tags: Stroke, Hypertension Cerebrovascular disease Source Type: research

Admission neutrophil-lymphocyte ratio predicts 90 day outcome after endovascular stroke therapy
Conclusions This study shows that the NLR, a readily available biomarker, may be a clinically useful tool for risk stratification when evaluating AIS patients as candidates for endovascular therapies.
Source: Journal of NeuroInterventional Surgery - September 5, 2014 Category: Neurosurgery Authors: Brooks, S. D., Spears, C., Cummings, C., VanGilder, R. L., Stinehart, K. R., Gutmann, L., Domico, J., Culp, S., Carpenter, J., Rai, A., Barr, T. L. Tags: Editor''s choice, Ischemic stroke Source Type: research