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Can the early use of botulinum toxin in post stroke spasticity reduce contracture development? A randomised controlled trial.
CONCLUSION: BoNTA reduced spasticity and contractures after stroke and effects lasted for approximately 12-weeks. BoNTA reduced the need for concomitant contracture treatment and did not interfere with recovery of arm function. TRIAL REGISTRATION: EudraCT (2010-021257-39) and ClinicalTrials.gov-Identifier: NCT01882556. PMID: 33040610 [PubMed - as supplied by publisher]
Source: Clinical Rehabilitation - October 11, 2020 Category: Rehabilitation Authors: Lindsay C, Ispoglou S, Helliwell B, Hicklin D, Sturman S, Pandyan A Tags: Clin Rehabil Source Type: research

Estimating the cost consequence of the early use of botulinum toxin in post-stroke spasticity: Secondary analysis of a randomised controlled trial
CONCLUSIONS: Treating spasticity early in stroke patients at risk of contractures with botulinum toxin leads to a significant reduction in contracture costs. The cost per improvement of Barthel and Action Research Arm Test indicates that the intervention costs less and is more effective.TRIAL REGISTRATION DATA: EudraCT(2010-021257-39) and ClinicalTrials.gov-Identifier:NCT01882556.PMID:36325678 | DOI:10.1177/02692155221133522
Source: Clinical Rehabilitation - November 3, 2022 Category: Rehabilitation Authors: Cameron Lindsay Ioan Humphreys Ceri Phillips Anand Pandyan Source Type: research

Heart Failure in Cardiac Rehabilitation: A REVIEW AND PRACTICAL CONSIDERATIONS
J Cardiopulm Rehabil Prev. 2022 Jul 14. doi: 10.1097/HCR.0000000000000713. Online ahead of print.ABSTRACTPURPOSE: Exercise cardiac rehabilitation (CR) represents an evidence-based therapy for patients with heart failure with reduced ejection fraction (HFrEF) and this article provides a concise review of the relevant exercise testing and CR literature, including aspects unique to their care.CLINICAL CONSIDERATIONS: A hallmark feature of HFrEF is exercise intolerance (eg, early-onset fatigue). Drug therapies for HFrEF target neurohormonal pathways to blunt negative remodeling of the cardiac architecture and restore favorable...
Source: Journal of Cardiopulmonary Rehabilitation and Prevention - July 15, 2022 Category: Rehabilitation Authors: Steven J Keteyian Alexander Michaels Source Type: research